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系所資訊
張正 教授

張 正 教授

美國匹茲堡大學生物無機及分析化學博士

專長:

製藥、化學、生物科技之企業、學術行政管理及經營;體內診斷及免疫藥劑之研究及發展;分析化學、分離及純化技術、生物無機化學、稀土離子配位化學; 醫學診斷、製藥、生物科技之市場情報研究、行銷及企畫

辦公室 :
台北市北投區112立農街二段155號實驗大樓4樓D308室 國立陽明大學生物醫學影像暨放射科學系

電話:(02)-28267000#7943(office) (02)2826-7000 #5120(lab)

電子信箱 :
cachang@ym.edu.tw

諮詢時間 : 週一、週三15:00-18:00



 

簡歷:

  • 美國衛斯理女子學院(Wellesley College)化學系助理教授
  • 美國麻省理工學院訪問學者
  • 美國德州大學終生職副教授
  • 美國鋁業公司生技組長
  • 美國必治妥施貴寶大藥廠研究組長
  • 美國Nycomed Salutar生技公司副總裁
  • 美國天虹(Grace)醫藥科技顧問公司總裁
  • 美國Frost & Sullivan醫藥情報公司主任
  • 美國國家衛生研究院Metallobiochemistry Study Section委員
  • 美國化學會Bioconjugate Chemistry編審委員
  • 國立交通大學生物科技所教授暨創所所長
  • 國立陽明大學生物醫學暨工程學院院長

Pre-and post-Gd MRI contrast agent administration
Proposed general hydrolysis behaviors of Ln(III)L complexes
Macrocyclic ligand DOTA is pre-organized for metal ion complexation: safer drug.
Macrocyclic ligand TETA is not pre-organized for metal ion complexation: less desirable drug candidate.
HSA IIIa binding site affinity study: MRI blood pool agent discovery

研究方向

A. 生物無機化學、診斷藥學、分子醫學:稀土離子之配位化學(大環配位子之合成和純化、配位化合物之熱力學、動力學、結構學、光譜學)及生醫科技之應用(組織專一性磁振造影劑、人造核酸限制脢、核醫藥劑、螢光分子探針)。


近期代表著作 :

  1. C.A. Chang*, Y.-L. Liu, C.-Y, Chen, X.-M. Chou, J.-S. Ho. “Ligand Preorganization in Metal Ion Complexation: Molecular Mechanics/Dynamics, Kinetics and the Laser-Excited Luminescence Studies of Trivalent Lanthanide Complex Formation with Macrocyclic Ligands DOTA and TETA”, Inorg. Chem., 2001, 40, 3448-3455. [SCI: 4.132; Rank: 4/43]
  2. C.A. Chang*, B.-H. Wu, P.-Y. Kuan. “Macrocyclic Lanthanide Complexes as Artificial Nucleases and Ribonucleases. Effects of pH, Metal Ionic Radii, Number of Coordinated Water Molecules, Charge and Concentrations of the Metal Complexes.” Inorg. Chem., 2005, 44, 6646-6654. [SCI: 4.132; Rank: 4/43]
  3. C.A. Chang*, Y.-P. Chen, C.-H. Hsiao. “Kinetics of BNPP Hydrolysis Reactions with Trivalent Lanthanide Complexes of N-Hydroxylethyl(ethylenediamine)-N,N’,N’-triacetate (HEDTA)”. Eur. J. Inorg. Chem., 2009, 1036-1042. [SCI: 2.597; Rank: 11/43]
  4. C.A. Chang*, C.-H. Hsiao, B.-H. Wu. “Effects of Concentration of Some Lanthanide(III) Complexes of 1,7-Bis(carboxymethyl)-1,4,7,10-tetraazacyclododecane (LnDO2A+) on BNPP Hydrolysis”, Eur. J. Inorg. Chem., 2009, 1339-1346. [SCI: 2.597; Rank: 11/43]

B. 生化工程及蛋白質化學、多醣生物化學:生化活性物質(多醣體、中草藥)之培育、分離、純化、大量表現、作用機理與結構及活性測試;惡性腫瘤、疾病辨識分子之研發; 骨骼(癌)細胞之生成與代謝。

近期代表著作 :

  1. K.-T. Chen, H.-F. Weng, C.A. Chang*, and E.-C. Chan*. “An Aberrant Autocrine Activation of the Platelet-derived Growth Factor α-Receptor in Follicular Thyroid Carcinoma Cell Line and Papillary Thyroid Carcinoma Cell Line.” Cancer Letters, 231 (2006) 192-205. [SCI: 3.398; Rank: 49/132].
  2. C.T. Lo, Y.-H. Jiang, A. L.-J. Chao, C.A. Chang*, “Use of statistical methods to interpret relationship between monosaccharide ratio and macrophage stimulatory activity of regionally different strains of Letinula Edodes”, Anal. Chim. Acta, 2007, 584, 50-56. [SCI: 3.186; Rank: 10/70].
  3. T.C.T. Lo, M.W. Kang, B.C. Wang, C.A. Chang*. “Glycosyl Linkage Characteristics and Classifications of Exo-polysaccharides of Some Regionally Different Strains of Lentinula edodes by Amplified Fragment Length Polymorphism Assay and Cluster Analysis”. Anal. Chim. Acta, 2007, 592, 146-153. [SCI: 3.186; Rank: 10/70].
  4. T.C.T. Lo, H.H. Tsao, A.Y. Wang, C.A. Chang*. “Pressurized Water Extraction of Polysaccharides as Secondary Metabolites from Lentinula edodes”. J. Agric. Food Chem., 2007, 55, 4196-4201. [SCI: 2.532; Rank: 1/35].
  5. S.-F. Chang, C.A. Chang*, D.-Y. Lee, P.-L. Lee, Y.-M. Yeh, C.-R. Yeh, C.-K. Cheng, S. Chien, J.-J. Chiu. “Tumor Cell Cycle Arrest Induced by Shear Stress: Roles of Integrins and Smad.” PNAS, 2008, 105, 3927-3932. [SCI: 9.598; Rank: 3/50].
  6. S.-F. Chang, C.-K. Cheng, S. Chien, C.A. Chang*, J.-J. Chiu*. “p21CIP1 and p27KIP1 are associated with Bone Morphogenetic Protein 4-induced osteoblast-like cell growth arrest and differentiation”. Mol. Endocrinol., 2009, in press. [SCI: 5.337; Rank: 13/92].
  7. Y.P. Kuo, C.A. Chang*, E.R. Chan*. “Identification and Clinical Associations of Anti-Cytokeratin 18 Autoantibody in Patients with Chronic Obstructive Pulmonary Disease". Eur. Respri. J., 2009, submitted (revision). [SCI: 5.545; Rank: 3/40].
  8. T.C.T. Lo, C.A. Chang*. “In Vitro Macrophage Stimulatory and Anti-tumor Activities and Enhancement of Macrophage Cell-Cell Communications of Polysaccharides from Some Regionally Different Strains of Lentinula edodes”, 2009, submitted (revision).


C. 生物分析化學、醫學工程:(奈米)生物檢測器、醫療診斷儀器、生物微機電。


近期代表著作 :

  1. S.-H. Lee, H.-Y. Fang, W.-C. Chen, H.-M. Lin, C.A. Chang*, “Electrochemical Study on the Screen-printed Carbon Electrodes with Modification by Iron Nanoparticles in Fe(CN)64-/3- Redox System.” Anal. Bioanal. Chem., 2005, 383:532-538. [SCI: 2.867; Rank: 17/70].
  2. Y.-H. Lin, T.Y. Shen, C.A. Chang*. “Reduction of the interferences of biochemicals and hematocrit ratio on the determination of whole blood glucose using multiple screen-printed carbon electrode (SPCE) test strips”, Anal. Bioanal. Chem., 2007, 389:1623-1631. [SCI: 2.867; Rank: 17/70].
  3. Y.-H. Lin, C.A. Chang*, C.S. Lin*, et al. “Amperometric immunosensing strips for the detection of foodborne pathogen Escherichia coli O157:H7 by Au nanoparticles-modified disposable screen printed carbon electrodes”, Biosensor & Bioelectronics, 2008, 23, 1832-1837. [SCI: 5.061; Rank: 3/70].
  4. Y.-H. Lin, Y.-C. Lu, S.-H. Chen, T.Y. Shen, C.-S. Lin*, C.A. Chang*. “Amperometric determinations of carbofuran and glutathione using screen-printed carbon electrode strips modified with gold nanoparticles, ferrocenedicarboxylic acid and tyrosinase”, 2009, submitted.

 

研究領域

研究領域-張正 教授

 


專利


  1. C. Allen Chang, et. al. “Contrast Media”, U.S. and PCT patent, 1992
  2. 李世煌、林岳暉、顏嘉妤、黃英哲、陳文章、林鴻明、張正、沈燕士,”電極試片及包含其之生物感測器Eectrode strip and biosensor comprising the same”,中華民國專利(核准日期2007/3/21;證書號碼I276799;專利年限2007/03/21-2025/9/15)。
  3. 李鴻文、林岳暉、張正、沈燕元、沈燕士,”酵素抑制劑的分析方法與模組”,中華民國(核准日期2007/12/11;證書號碼I291026;專利年限2005/07/26-2025/7/25)、中國(申請日2005/8/5;申請案號 200510089748.4)。
  4. 張正、林穎男,”供降低糖尿病患者血糖之複合物”,中華民國(核准日期2009/08/01;證書號碼I312685;專利年限2009/08/01-2026/01/05)
  5. 林岳暉、王瑞萍、鄭懿芳、許玉森、許銘昌、楊孟文、張正、沈燕士。定量分析酵素抑制劑的檢測裝置及方法Apparatus and Method for Quantitative Analyzing Enzyme Inhibitor,中華民國(申請日2006/11/6;申請案號 95140989)、中國(申請日2006/11/6;申請案號200610144572.2)、美國(申請日2007/11/6;申請案號11/979620)。
  6. 林岳暉、朱清淵、陳冠廷、陳德合、王瑞萍、張正、沈燕士,”電化學定量分析系統及方法Electrochemical quantitative analysis system and method for the same”,中華民國(申請日2007/9/21;申請案號96135313)、中國(申請日2007/9/21;申請案號200710152909.9)、美國(申請日2008/9/21;申請案號12/234659)。