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系所資訊
王信二 教授

放射化學暨分子造影實驗室

王信二 教授

臺灣大學,化學博士

專長:放射化學、核醫藥物學、核子醫學
辦公室:實驗大樓 B328室
電話:(02)2826-7215(office) (02)2826-7000 #5596、#5234(lab)
電子信箱:hewang@ym.edu.tw
諮詢時間:週一.週五 14:00 ~ 17:00



王信二老師與實驗室全體成員

 

研究領域

研究領域-王信二 教授

 

研究興趣


  由於核醫製藥及影像儀器的進步,現今生物體內的生理動態變化 (甚至思考)均能以核醫影像呈現,過去科幻小說中的「I can read your mind」,也許在不久的將來可藉 助正子掃瞄偵測特定腦組織的活動影像來做到。
  目前幾乎大部份疾病均可用核醫造影來診斷,現今最熱門的基因治 療,也需藉助核醫藥物作為基因探針,再經由核醫造影術來預測基因治療成功之可能性。另外,核醫藥物用 在各種腫瘤、甲狀腺及關節滑膜等疾病的治療,更是未來最具潛力的發展方向。

   本實驗室已完成或正在執行中的研究及成果發表:

 


     腫瘤代謝速率追蹤-葡萄糖代謝18F-FDG;胺基算代謝18F-FET;脂肪酸合成18F-FAc

  • Ren-Shyan Liu, Ta-Kai Chou, and Hsin-Ell Wang*, et al. Biodistribution, Pharmacokinetics and PET Imaging of [18F]FMISO, [18F]FDG and [18F]FAc in a sarcoma- and inflammation-bearing mouse model. Nucl Med Biol 2009;36:305-312.
  • Chih-Hsien Chang, Hsin-Ell Wang, and Ying-Kai Fu, et al. Comparative evaluation of 18F-FET and 18F-FDG for differentiating lung carcinoma from inflammation in mice. Anticancer Research 2006;26:917-926
  • Hsin-Ell Wang, Shih-Yen Wu, and Jeng-Jong Hwang, et al. Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model. Nucl Med Biol 2005;32(4):367~375

     

     硼中子捕獲治療治療前評估-18F-FBPA-Fr

  • Chun-Yi Wu, Pei-Chia Chan, and Hsin-Ell Wang*, et al. Pulsed focused ultrasound enhances boron drug accumulation in a human head and neck cancer xenograft-bearing mouse model. Molecular Imaging & Biology 2013 (Accepted)
  • C.H. Hsieh, H.M. Liu, J.J. Hwang, H.E. Wang, J.J. Kai, F.D. Chen. A simple model for quantification of the radiobiological effectiveness of the 10B(n,a)7Li capture reaction in BNCT. Appl Radiat Isotoptpes 2006;64:306-314
  • Chia-Hung Hsieh, Yu-Fang Chen, and Hsin-Ell Wang, et al. Evaluation of pharmacokinetics of 4-bromo-2-18F-fluoro-L-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperomolar blood-brain berrier disruption. J Nucl Med 2005;46:2-18
  • J.C.Chen, S.M.Chang, H.E.Wang, and R.S.Liu et al. MicroPET-based pharmacokinetic analysis of the radiolabeled boron compound [18F]FBPA-F in rats with F98 glioma. Appl Radiat Isotoptpes 2004;61:887-891.
  • Hsin-Ell Wang, Ai-Ho Liao, and Jeng-Jong Hwang, et al. Evaluation of 4-Borono-2-18F-Fluoro-L-Phenylalanine-Fructose as a Probe for Boron Neutron Capture Therapy in a Glioma-Bearing Rat Model. J Nucl Med 2004;45:2-18

     

     放射性標誌微脂體包覆藥物之藥動研究

  • Yi-Yu Lin, Hao-Wen Kao, and Hsin-Ell Wang*, et al. Tumor burden talks in cancer treatment with PEGylated liposomal drugs. PLoS One 2013;8(5): e63078.
  • Feng-Yi Yang, Hsin-Ell Wang, and Tai-Tong Wong, et al. Pharmacokinetic analysis of 111In-labeled liposomal Doxorubicin in murine glioblastoma after blood-brain barrier disruption by focused ultrasound. PLoS One 2012;7:e45468
  • Yi-Yu Lin, Chih-Hsien Chang, and Hsin-Ell Wang*, et al. Pharmacokinetics and dosimetry of 111In/188Re-labeled PEGylated liposomal drugs in two colon carcinoma-bearing mouse models. Cancer Biotherapy & Radiopharmaceuticals 2011;26:373-380
  • Tong-Hsien Chow, Yi-Yu Lin, Hsin-Ell Wang, and Gann Ting, et al. Therapeutic efficacy evaluation of 111In-labeled PEGylated liposomal vinorelbine in murine colon carcinoma with multimodalities of molecular imaging. J Nucl Med 2009;50:2073-81
  • Lin YY, Li JJ, and Wang HE, et al. Evaluation of pharmacokinetics of 111In-labeled VNB-PEGylated liposomes after intraperitoneal and intravenous administration in a tumor/ascites mouse model. Cancer Biotherapy & Radiopharmaceuticals 2009;24:453-460
  • Tong-Hsien Chow, Yi-Yu Lin, Hsin-Ell Wang, and Gann Ting, et al. Improvement of biodistribution and therapeutic index via increase of polyethylene glycol on drug-carrying liposomes in an HT-29/luc xenografted mouse model. Anticancer Research 2009;29:2111-2120
  • Tong-Hsien Chow, Yi-Yu Lin, Hsin-Ell Wang, and Gann Ting, et al. Diagnostic and therapeutic evaluation of 111In-vinorelbine-liposomes in a human colorectal carcinoma HT-29/luc-bearing animal mode. Nucl Med Biol 2008;35:623-634
  • Ya-Fang Chang, Yi-Yu Lin, Hsin-Ell Wang and Jeng-Jong Hwang, et al. Monitoring of tumor growth and metastasis potential in MDA-MB-435s/tk-luc human breast cancer xenografts. Nucl Instrum Meth A 2007;571:155-159
  • Hsin-Ell Wang, Hung-Man Yu, and Win-Ping Deng, et al. Internal radiotherapy and dosimetry study for 111In/177Lu-pegylated liposomes conjugates in tumor-bearing mice. Nucl Instrum Meth A 2006;569:533-537

   

     核苷酸衍生物

        基因造影劑及其應用-18F-FEAU,18F-FIAU,18F-FIAC,18F-FHPG,18F-FBPG
 

  • Pei-Chia Chan, Chun-Yi Wu, Hsin-Ell Wang*, et al. Evaluation of F-18-labeled 5-iodocytidine (18F-FIAC) as a new potential positron emission tomography probe for herpes simplex virus type 1 thymidine kinase imaging. Nucl Med Biol 2011;38:987-995.
  • Chun-Yi Wu, Pei-Chia Chan, and Hsin-Ell Wang*, et al. Radiosynthesis of F-18 labeled cytidine analogue 2'-fluoro-5-iodo-l-β-D-arabinofuranosylcytosine ([18F]FIAC). Appl Radiat Isotopes 2009;67:1362-1365
  • Chia-Hung Hsieh, Fu-Du Chen, Hsin-Ell Wang, and Ren-Shyan Li, et al. Generation of Destabilized Herpes Simplex Virus Type 1 Thymidine Kinase as Transcription Reporter for PET Reporter Systems in Molecular–Genetic Imaging. J Nucl Med 2008;49:142-150
  • Steve R. Roffler, Hsin-Ell Wang, Hung-Man Yu, and Tian-Lu Cheng, et al. A membrane antibody receptor for noninvasive imaging of gene expression. Gene Therapy 2006;13:412-420
  • Win-Ping Deng, Wen K. Yang, and Hsin-Ell Wang*, et al. Non-invasive in vivo imaging with radiolabeled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. Eur. J. Nucl. Med. Mol. Imag 2004;31(1):99-109.
  • Chi-Wei Chang, Mai Lin, and Hsin-Ell Wang*, et al. A high yield robotic synthesis of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro- 1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) for gene expression imaging. Appl Radiat Isotopes 2007;65:57-63
  • Hsin-Ell Wang, Hung-Man Yu,and Win-Ping Deng, et al. Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer. J. Nucl Med 2006;47:1161-1171
  • Win-Ping Deng, Cheng-Chia Wu, Hsin-Ell Wang, and Cheng-Wen Wu, et al. Serial In Vivo Imaging of the Lung Metastases Model and Gene Therapy Using HSV1-tk and Ganciclovir. J. Nucl Med 2006;47:877-88

     

     腫瘤治療-131I-IUdR

  • Hung-Man Yu, Hsin-Pei Yeh, and Hsin-Ell Wang*, et al. Improved targeting of 5-[125I/131I]iodo-2'-deoxyuridine to rat hepatoma by using lipiodo emulsion. Nucl Instrum Meth A 2006;569:538-542
  • Hsin-Ell Wang, Hui-Chuan Wu, and Kwan-Hwa Chi, et al. Modulation of 5-fluorouracil cytotoxicity through thymidylate synthase and NF-κB down-regulation and its application on the radiolabelled iododeoxyuridine therapy on human hepatoma cell. Biochemical Pharmacology 2005;69:617-626

     腫瘤增生造影劑及其應用-18F-FMAU,18F-FLT,123I-ICdR

  • Pei-Chia Chan, Chun-Yi Wu, and Hsin-Ell Wang*, et al. Monitoring Tumor Response with [18F]FMAU in a Sarcoma-bearing Mouse Model after Liposomal Vinorelbine Treatment. Nucl Med Biol 2013 (Accepted)
  • Wen-Yi Chang, Wei-Ti Kuo, Hsin-Ell Wang* and Chuan-Lin Chen*, et al. Evaluation of 131/123I-5-iodo-2'-deoxycytidine as a novel proliferation probe in a tumor mouse model. Appl Radiat Isotopes 2013;77:166-173.
  • Chun-Yi Wu, Lin-Shan Chou, and Hsin-Ell Wang*, et al. Monitoring tumor response with radiolabeled nucleoside analogues in a hepatoma-bearing mouse model early after DoxisomeR treatment. Molecular Imaging & Biology 2013;15(3):326-335.
  • Chun-Yi Wu, Hsin-Ell Wang*, Ming-Hsien Lin, et al. Radiolabeled nucleosides for predicting and monitoring the cancer therapeutic efficacy of chemodrugs. Curr Med Chem 2012;19:3315-3324.


     腦神經疾病造影劑

                  帕金森氏症 (多巴胺神經系統造影劑) —18F-FDOPA

  • C.W. Chang, H.E. Wang, and R.S. Liu, et al. Robotic synthesis of 6-[18F]fluoro-dopa. Nucl. Med. Commun. 2000;21:799-802
  • H. E. Wang, C. W. Chang and H. M. Lin, et al. Radiosynthesis of 6-[18F]fluoro-L-FDOPA for dopaminergic function imaging with PET. Ann. Nucl. Med. Sciences 1999;12(1):1-6


     血清素轉運體造影劑—ADAM

  • Kang-Wei Chang, Chia-Chieh Chen, Shih-Ying Lee and Hsin-Ell Wang*. Development of acute and subacute toxicity with the serotonin transporter radiopharmaceutical, ADAM. Drug and Chemical Toxicology 2010;33:393-402


     阿茲海默症

  • Kang-Wei Chang; Chia-Chieh Chen; Shih-Ying Lee and Hsin-Ell Wang*. Acute toxicity of two Alzheimer's disease radiopharmaceuticals: FDDNP and IMPY. Drug and Chemical Toxicology 2009;32:429-437
  • K.W.Chang, C.C.Chen, S.H.Lee, L.H.Shen and H.E.Wang. The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer’s disease. Appl Radiat Isotopes 2009;67:1397-1400

   

     缺氧組織造影劑

  • Chien-Chung Hsia, Fu-Lei Huang, and Hsin-Ell Wang*, et al. The biological characterization of 99mTc-BnAO-NI as a SPECT probe for imaging hypoxia in a sarcoma-bearing mouse model. Appl Radiat Isotopes 2011;69(4):649-655
  • Chien-Chung Hsia, Fu-Lei Huang, and Hsin-Ell Wang*, et al. The preparation and biological characterization of new HL91-derivative for hypoxic imaging on stroke mice. Appl Radiat Isotopes 2010;68(9):1610-1615
  • C.W. Chang, T.K. Chou, and H.E. Wang, et al. A robotic synthesis of [18F]fluoromisonidazole ([18F]FMISO). Appl Radiat Isotopes 2007;65:682-686  

實驗室成員


碩士班 (入學年度)

  1. 林立芳-高雄醫學大學醫學系畢業(102)
  2. 阮偉程-陽明大學大學醫放系畢業(102)
  3. 唐若心-陽明大學醫放系畢業(101)
  4. 駱彥辰-高雄醫學大學 醫檢醫放雙學位(100)
  5. 謝有玲-陽明大學醫放系畢業(100)

博士班 (入學年度)

  1. 陳昭政-陽明大學醫放系畢業(102)
  2. 甘國邑-中台科技大學醫放系畢業(101)

生涯職業規劃-放化師


放化師簡介
https://docs.google.com/presentation/d/1YdQ-W-6rA8wlpRiOsw-TfGT1ZuL6FPF8sM1S2VFuxPk/pub?start=false&loop=false&delayms=3000#slide=id.g2bc5284d4_011


學術著作


期刊論文
  1. Kuo-Hsiang Chuang, Hsin-Ell Wang# (co-first author), Ta-Chun Cheng, Shey-Cherng Tzou, Chiu-Min Cheng, Chien-Han Kao, Chih-Hung Chung, Wei-Lung Tseng, Wen-Chun Hung, Ming-Hong Tai, Tien-Kuei Chang, Bing-Mae Chen, Steve R. Roffler and Tian-Lu Cheng*. Development of a universal anti-polyethylene glycol reporter gene for noninvasive imaging of PEGylated probes. J Nucl Med (2010) 51:933-941.
  2. Kuo-Hsiang Chuang, Hsin-Ell Wang# (co-first author), Fang-Ming Chen, Shey-Cherng Tzou, Chiu-Min Cheng, Ya-Chen Chang, Wei-Lung Tseng, Jentaie Shiea, Shiu-Ru Lin, Jaw-Yuan Wang, Bing-Mae Chen8, Steve R. Roffler and Tian-Lu Cheng. Endocytosis of PEGylated agents enhances cancer imaging and anti-cancer efficacy. Mol Cancer Ther (2010) 9(6):1903-1912.
  3. Chien-Chung Hsia, Fu-Lei Huang, Cheng-Hsien Lin, Lie-Hang Shen and Hsin-Ell Wang*. The preparation and biological characterization of new HL91-derivative for hypoxic imaging on stroke mice. Appl Radiat Isot (2010) 68:1610-1615.
  4. Kang-Wei Chang; Chia-Chieh Chen; Shih-Ying Lee and Hsin-Ell Wang*. Development of acute and subacute toxicity with the serotonin transporter radiopharmaceutical, ADAM. Drugs and Chemical Toxicology (2010) 33:393-402.
  5. Shey-Cherng Tzou, Steve Roffler, Kuo-Hsiang Chuang, Hsin-Pei Yeh, Chien-Han Kao, Yu-Cheng Su, Chiu-Min Cheng, Wei-Lung Tseng, Jentaie Shiea, Kai-Wen Cheng, Bing-Mae Chen, Tian-Lu Cheng and Hsin-Ell Wang. Micro-PET imaging of β-glucuronidase activity by the hydrophobic conversion of a glucuronide probe. Radiology (2009) 252(3):754-62
  6. Kang-Wei Chang, Chia-Chieh Chen, Shih-Ying Lee and Hsin-Ell Wang*. Acute toxicity of two Alzheimer's disease radiopharmaceuticals: FDDNP and IMPY. Drugs and Chemical Toxicology (2009) 32(4):429-437
  7. Ren-Shyan Liu, Ta-Kai Chou, Chih-Hsien Chang, Chun-Yi Wu, Chi-Wei Chang, Tsui-Jung Chang, Shih-Jen Wang, Wuu-Jyh Lin and Hsin-Ell Wang. Biodistribution, Pharmacokinetics and PET Imaging of [18F]FMISO, [18F]FDG and [18F]FAc in a sarcoma- and inflammation-bearing mouse model. NUCLEAR MEDICINE AND BIOLOGY 2009;36:305-312 (SCI).(Impact factor: 2.478;Rank: 29.89%)
  8. Chi-Wei Chang, Yi-Yu Lin, Chi-Jung Peng, Mai Lin, Ren-Shyan Liu, Shyh-Jen Wang, Wuu-Jyh Lin and Hsin-Ell Wang*. The robotic radiosynthesis of 5-[18F]fluoro-2'- deoxyuridine and its biological characterization. APPLIED RADIATION AND ISOTOPES 2009;: (SCI).(Impact factor: 1.008;Rank: 25.81%)
  9. K.W.Chang, C.C.Chen, S.H.Lee, L.H.Shen and H.E.Wang*. The synthesis and characterization of [124I]IMPY, a thioflavin-S derivative, in transgenic mouse models of Alzheimer’s disease. APPLIED RADIATION AND ISOTOPES 2009;: (SCI).(Impact factor: 1.008;Rank: 25.81%)
  10. Chun-Yi Wu, Pei-Chia Chan, Wei-Ting Chang, Ren-Shyan Liu, Mian M Alauddin and Hsin-Ell Wang*. Radiosynthesis of F-18 labeled cytidine analogue 2'-fluoro-5-iodo-l-β-D- arabinofuranosylcytosine ([18F]FIAC). APPLIED RADIATION AND ISOTOPES 2009;: (SCI).(Impact factor: 1.008;Rank: 25.81%)
  11. Chia-Hung Hsieh, Fu-Du Chen, Hsin-Ell Wang, Jeng-Jong Hwang, Chi-Wei Chang, Yi-Jang Lee, Juri G. Gelovani, and Ren-Shyan Liu. Generation of Destabilized Herpes Simplex Virus Type 1 Thymidine Kinase as Transcription Reporter for PET Reporter Systems in Molecular–Genetic Imaging. JOURNAL OF NUCLEAR MEDICINE 2008;49:142-150 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  12. Tong-Hsien Chow, Yi-Yu Lin, Jeng-Jong Hwang, Hsin-Ell Wang, Yun-Long Tseng, Victor Fei Pang, Shyh-Jen Wang, Jacqueline Whang-Peng, Gann Ting. Diagnostic and therapeutic evaluation of 111In-vinorelbine-liposomes in a human colorectal carcinoma HT-29/luc-bearing animal mode. NUCLEAR MEDICINE AND BIOLOGY 2008;35:623-634 (SCI).(Impact factor: 2.478;Rank: 29.89%)
  13. Ya-Ju Hsieh, Fu-Du Chen, Fu Hui Wang, Chien Chih Ke, Hsin-Ell Wang and Ren-Shyan Liu. Molecular switch of Cre/loxP for radiation modulated gene therapy on hepatoma. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2007;571:453-456 (SCI).(Impact factor: 1.114;Rank: 12.90%)
  14. Ya-Fang Chang, Yi-Yu Lin, Hsin-Ell Wang, Ren-Shyan Liu, Fei Pang and Jeng-Jong Hwang. Monitoring of tumor growth and metastasis potential in MDA-MB-435s/tk-luc human breast cancer xenografts. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2007;571:155-159 (SCI).(Impact factor: 1.114;Rank: 12.90%)
  15. C.W. Chang, T.K. Chou, R.S. Liu, S.J. Wang, W.J. Lin, C.H. Chen and H.E. Wang. A robotic synthesis of [18F]fluoromisonidazole ([18F]FMISO). APPLIED RADIATION AND ISOTOPES 2007;65:682-686 (SCI).(Impact factor: 1.008;Rank: 25.81%)
  16. Ya-Ju Hsieh, Ren-Shyan Liu, Luen Hwu, Chien Chih Ke, Fu Hui Wang, Hsin-Ell Wang and Fu-Du Chen. Cre/loxP system controlled by specific promoter for radiation-mediated gene therapy of hepatoma. ANTICANCER RESEARCH 2007;27:1571-1580 (SCI).(Impact factor: 1.414;Rank: 81.82%)
  17. Chi-Wei Chang, Mai Lin, Shih-Yen Wu, Chia-Hung Hsieh, Ren-Shyan Liu, Shyh-Jen Wang, Kuang-Liang Huang, Chin-Hsiung Chen, Hsin-Ell Wang. A high yield robotic synthesis of 9-(4-[18F]-fluoro-3-hydroxymethylbutyl)guanine ([18F]FHBG) and 9-[(3-[18F]fluoro- 1-hydroxy-2-propoxy)methyl]guanine ([18F]FHPG) for gene expression imaging. APPLIED RADIATION AND ISOTOPES 2007;65:57-63 (SCI).(Impact factor: 1.008;Rank: 25.81%)
  18. Steve R. Roffler, Hsin-Ell Wang, Hung-Man Yu, Wen-Da Chang, Chiu-Min Cheng, Yu-Ling Lu, Bing-Mae Chen, Tian-Lu Cheng. A membrane antibody receptor for noninvasive imaging of gene expression. Gene Therapy 2006;13:412~420 (SCI).(Impact factor: 4.812;Rank: 9.42%)
  19. Chih-Hsieh Chang, Mei Lin, Kuo-Hsien Fan, Hsin-Ell Wang, Tung-Hu Tsai, Chieh-Fu Chen, Ying-Kai Fu, Te-Wei Lee. Longitudinal evaluation of tumor metastasis by an FDG-microPET/microCT dual-imaging modality in a lung carcinoma-bearing mouse model. Anticancer Research 2006;26:159~166 (SCI).(Impact factor: 1.414;Rank: 81.82%)
  20. Chih-Hsien Chang, Hsin-Ell Wang, Shih-Yen Wu, Kuo-Hsien Fan, Tung-Hu Tsai, Te-Wei Lee, Chang SR, Ren-Shyan Liu, Chen CF, Chin-Hsiung Chen, Ying-Kai Fu. Comparative evaluation of 18F-FET and 18F-FDG for differentiating lung carcinoma from inflammation in mice. Anticancer Research 2006;26:917~926 (SCI).(Impact factor: 1.414;Rank: 81.82%)
  21. C.H. Hsieh, H.M. Liu, J.J. Hwang, H.E. Wang, J.J. Kai, F.D. Chen. A simple model for quantification of the radiobiological effectiveness of the 10B(n,a)7Li capture reaction in BNCT. APPLIED RADIATION AND ISOTOPES 2006;64:306~314 (SCI).(Impact factor: 1.008;Rank: 25.81%)
  22. Hung-Man Yu, Hsin-Pei Yeh, Tien-Kui Chang, Kuang-Liang Huang, Kuo-Tang Chuang, Ren-Shen Liu, Shyh-Jen Wang, Jeng-Jong Hwang, Kwan-Hwa Chi, Fu-Du Chen, Wuu-Jyh Lin, Chin-Hsiing Chen, Hsin-Ell Wang. Improved targeting of 5-[125I/131I]iodo-2'-deoxyuridine to rat hepatoma by using lipiodo emulsion. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2006;569:538-542 (SCI).(Impact factor: 1.114;Rank: 12.90%)
  23. Hsin-Ell Wang, Hung-Man Yu, Yi-Ching Lu, Ning-Ning Heish, Yun-Long Tseng, Kuang-Liang Huang, Kuo-Teng Chuang, Chin-Hsiung Chen, Jeng-Jong Hwang, Wuu-Jyh Lin, Shyh-Jen Wang, Gann Ting, Jacqueline Whang-Peng, Win-Ping Deng. Internal radiotherapy and dosimetry study for 111In/177Lu-pegylated liposomes conjugates in tumor-bearing mice. NUCLEAR INSTRUMENTS & METHODS IN PHYSICS RESEARCH SECTION A-ACCELERATORS SPECTROMETERS DETECTORS AND ASSOCIATED EQUIPMENT 2006;569:533-537 (SCI).(Impact factor: 1.114;Rank: 12.90%)
  24. Win-Ping Deng, Cheng-Chia Wu, Chien-Chih Lee, Wen K. Yang, Hsin-Ell Wang, Ren-Shyan Liu, Hon-Jian Wei, Juri G. Gelovani, Jeng-Jong Hwang, Den-Mei Yang, Ying-Kai Fu, and Cheng-Wen Wu. Serial In Vivo Imaging of the Lung Metastases Model and Gene Therapy Using HSV1-tk and Ganciclovir. JOURNAL OF NUCLEAR MEDICINE 2006;47:877-88 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  25. Hsin-Ell Wang, Hung-Man Yu, Ren-Shyan Liu, Mai Lin, Juri G. Gelovani, Jeng-Jong Hwang, Hon-Jian Wei, Win-Ping Deng. Molecular imaging with 123I-FIAU, 18F-FUdR, 18F-FET and 18F-FDG for monitoring herpes simplex virus type 1 thymidine kinase and ganciclovir prodrug activation gene therapy of cancer. Journal of Nuclear Medicine 2006;47:1161~1171 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  26. Chia-Hung Hsieh, Yu-Fang Chen, Fu-Du Chen, Jeng-Jong Hwang, Jyh-Cheng Chen, Ren-Shen Liu, Ji-Jung Kai, Hsin-Ell Wang. Evaluation of pharmacokinetics of 4-bromo-2-18F-fluoro-L-phenylalanine for boron neutron capture therapy in a glioma-bearing rat model with hyperomolar blood-brain berrier disruption. Journal of Nuclear Medicine 2005;46:2-18 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  27. Hsin-Ell Wang, Shih-Yen Wu, Chi-Wei Chang, Ren-Shen Liu, Li-Chung Hwang, Te-Wei Lee, Jyh-Cheng Chen and Jeng-Jong Hwang.. Evaluation of F-18-labeled amino acid derivatives and [18F]FDG as PET probes in a brain tumor-bearing animal model(in press). Nuclear Medicine and Biology 2005;32(4):367~375 (SCI).(Impact factor: 2.478;Rank: 29.89%)
  28. Hsin-Ell Wang, Hui-Chuan Wu, Shang-Jyh Kao, Fan-Wei Tseng, Yu-Shan Wang, Hung-Man Yu , Shun-Lan Chou, Sang-Hue Yen and Kwan-Hwa Chi.. Modulation of 5-fluorouracil cytotoxicity through thymidylate synthase and NF-κB down-regulation and its application on the radiolabelled iododeoxyuridine therapy on human hepatoma cell. BIOCHEMICAL PHARMACOLOGY 2005;69:617-626 (SCI).(Impact factor: 4.006;Rank: 15.61%)
  29. Shang-Lung Dong, Tieh-Chi Chu, Hung-Man Yu, Yu-Hsiu Yeh, Gong-Yau Lan, Yung-Chien Lin, Hsin-Ell Wang, Sang-Hue Yen. Investigation of polymer BANG gel dosimetry using X-ray computed tomographic imaging. Journal of Medical and Biological Engineering 2005;25(1):1~6 (SCI).
  30. Ying-Ta Wu, Weir-Torn Jiang, Kuo-Ging Lin, Chun-Ming Huang, Chin-Hsin Chang, Ying-Ling Sun, Kuo-Hsien Fan, Wei-Chuan Hsu, Hsin-Ell Wang, Shwu-Bin Lin, Shui-Tein Chen. A new N-acetylgalacoprotein containing peptide as a targeting vehicle for mammalian hepatocytes via Asialoglycoprotein receptor endocytosis. Current Drug Delivery 2004;1:119~127 (SCI).
  31. Win-Ping Deng, Wen K. Yang, Wen-Fu Lai, Ren-Shyan Liu, Jeng-Jong Hwang, Den-Mei Yang, Ying-Kai Fu , Hsin-Ell Wang. Non-invasive in vivo imaging with radiolabeled FIAU for monitoring cancer gene therapy using herpes simplex virus type 1 thymidine kinase and ganciclovir. European Journal of Nuclear Medicine and Molecular Imaging 2004;31(1):99-109 (SCI).(Impact factor: 4.101;Rank: 9.20%)
  32. Kwan-Hwa Chi, Hsin-Ell Wang, Yu-Shan Wang, Shun-Lan Chou, Hung-Man Yu, Yu-Hwa Tseng, Ing-Ming Hwang and Wing-Yiu Lui. Antisense thymidilate synthase electrogene transfer to increase uptake of radiolabeled iododeoxyuridine in a murine model. Journal of Nuclear Medicine 2004;45:478-484 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  33. Hsin-Ell Wang, Ai-Ho Liao, Win-Ping Deng, Pi-Fang Chang, Jyh-Cheng Chen, Fu-Du Chen, Ren-Shen Liu, Jin-Shin Lee, and Jeng-Jong Hwang. Evaluation of 4-Borono-2-18F-Fluoro-L-Phenylalanine-Fructose as a Probe for Boron Neutron Capture Therapy in a Glioma-Bearing Rat Model. Journal of Nuclear Medicine 2004;45:2-18 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  34. J.C.Chen, S.M.Chang, F.Y.Hsu, H.E.Wang, R.S.Liu.. MicroPET-based pharmacokinetic analysis of the radiolabeled boron compound [18F]FBPA-F in rats with F98 glioma. Applied Radiation and Isotopes 2004;61:887-891 (SCI).(Impact factor: 1.008;Rank: 25.81%)
  35. C. C. Hsia, H. E. Wang, S. P. Wey, R. S. Liu and L. H. Shen.. Biodistribution study of 99mTc-HL91 in sarcoma-bearing mice. Ann. Nucl. Med. Sciences 2003;16(3):131-136 (OI).
  36. G. U. Hung, Y. C. Weng, W. Y. Lin, S. J. Wang, C. C. Hsia, S. P. Wey, H. E. Wang, C. H. Lin, L. H. Shen and G Ting.. Preliminary study of 99mTc-HL91 on a tumor mouse model. Ann. Nucl. Med. Sciences 2002;15(2):85-91 (OI).
  37. W.P Deng, C.H. Chang, W.F. Lai, H.E. Wang, G. Ting, W.K. Yang and R.S. Liu.. Non-invasive mapping of gene expression for gene therapy with molecular nuclear medicine imaging. Ann. Nucl. Med. Sciences. 2001;14(4):237-246 (OI).
  38. Kwan-Hwa Chi, Hsin-Ell Wang, Fu-Du Chen, Yee Chao, Ren-Shyan Liu, Shuan-Lan Chou, Yu-Shan Wang and Sang-Hue Yen.. Pre-Clinical Evaluation of Loco-Regional Delivery of Radiolabelled Iododeoxyuridine and Thymidylate Synthase Inhibitor in Hepatoma Model. Journal of Nuclear Medicine 2001;42:345-351 (SCI).(Impact factor: 5.915;Rank: 2.30%)
  39. F.D. Chen, B.T. Hsieh, H.E. Wang, Y.H Ou,W.K. Yang, J. Whang-Peng, R.S. Liu, F.F. Knapp, G. Ting and S.H. Yen.. Efficacy of Re-188-labeled sulphur colloid on prolongation of survival time in melanoma-bearing animals. Nuclear Medicine and Biology 2001;28:835-844 (SCI).(Impact factor: 2.478;Rank: 29.89%)
  40. F. D. Chen, M.C. Wu, H.E. Wang, J. J. Hwang, C. Y. Hong, Y. T. Huang, S. H. Yen and Y. H. Ou.. Sensitization of a tumor, but not normal tissue, to the cytotoxic effect of ionizing radiation using Panax Notoginseng extract. Ammerican Journal of Chinese Medecine 2001;29:517-524 (SCI).
  41. C.W. Chang, H.E. Wang, H.M. Lin, C.S. Chtsai, J.B. Chen and R.S. Liu. Robotic synthesis of 6-[18F]fluoro-dopa. Nucl. Med. Commun. 2000;21:799-802 (SCI).
  42. H. E. Wang, C. W. Chang and H. M. Lin, et al.. Radiosynthesis of 6-[18F]fluoro-L-FDOPA for dopaminergic function imaging with PET. Ann. Nucl. Med. Sciences 1999;12(1):1-6 (OI).
  43. H. E. Wang, K. H. Chi, S. H. Yen, F. D. Chen, W. L. Chow, K. L. Huang, S. P. Wey and G. Ting. The preparation and formulation study on 5-[125/131I]-iodo-2’-deoxyuridine radiopharmaceutical for hepatoma therapy. Therapeutic Radiology and Oncology 1998;5(4):285-291 (OI).
  44. S. J. Wang, W. Y. Lin and H. E Wang, et al.. The quality assurance test of 1-131 cellulose. Ann. Nucl. Med. Sciences 1995;8:1-131 (OI).
  45. S. C. Tsai, H. E. Wang, C. T. Huang, L.M.Yiin and S,T.Liu. Study of effects on the coordination of thioether ligands2 Stereospecific ligand substitutions in manganese(I) complexes. Chem. Ber 1995;128:151-155 (SCI).
  46. H. E. Wang, M. C. Cheng, S. M. Peng and S. T. Liu. Structure of p,p',S-[2,2-bis(diphenylphosphino)methy]-l- phenylthiopropane] tricarbonyltungsten (0). Acta Crystal 1995;C51:98-200 (SCI).
  47. 童永黔, 伍德馨, 王信二. 核能研究所迴旋加速器研製碘-123之系列核醫藥物研究. INER-T2065 1995;: (OI).
  48. 王美惠, 王信二, 陳敏男. 碘標幟血清白蛋白穩定性評估-新腸胃道出血診斷試劑之初步研究. INER-T2131 1995;: (OI).
  49. 王信二, 黃廣良, 吳俊彥, 蔡潤杰. 心肌造影劑對-碘苯基脂肪酸之研製, (1) 碘-123-IPPA 及 BMIPPA 之標幟與純化, . INER-T2142 1995;: (OI).
  50. 黃廣良, 王信二, 沈立漢. 鎝-99m-DMS核醫藥物體內輻射吸收劑量評估. 核子醫學雜誌 1995;8:5-20 (OI).
  51. 李銘析, 王信二, 沈立漢, 黃亨通. 核研碘-123-碘化鈉膠囊劑之研製及線上品管分析. INER-T2146 1995;: (OI).
  52. 王信二, 沈立漢, 吳俊彥. 腎功能造影劑I-123-0IH之備製研究. INER-T1963 1994;:123-120 (OI).
  53. 王信二, 沈立漢, 丁幹. 放射性碘標幟技術回顧. INER-1196 1994;: (SCI).
  54. H. E. Wang, M. C. Cheng, G. H. Lee, S. M. Peng and S. T. Liu. Coordination of a tripodal phosphine sulfide P2S toward various transition metal ions. J. Organomet. Chem. 1993;445:171-179 (SCI).
  55. S. T. Liu, H. E. Wang, S. C. Tsai, G. J. Liu, et al.. Study of the effects on coordination of thioether sites 1 Complexation study of bromopentacarbonyl manganese (I) with tripodal P3-nSn (n=O-3) ligands. Organometallics 1993;12:2277-2283 (SCI).(Impact factor: 3.833;Rank: 13.95%)
  56. 信二, 沈立漢, 丁幹. Dopamine 受體藥物化學之現況與展望. 化學 1992;50(4):395-414 (OI).
  57. 丁幹, 王信二. 同位素與輻射應用. INER-T1622 1992;: (OI).
  58. H. E. Wang, C. Y. Liu, S. T. Liu, et al. Nitrogen-containing tripodal ligands. Phosphorus, Sulfur and Silicon 1992;69:201-211 (SCI).
  59. H. E. Wang, S. T. Liu, et al.. Synthesis and coordination of tripodal-containing copper(I) complexes. J. Chinese Chem. Soc. 1991;38:565-572 (SCI).
  60. S. T. Liu, H. E. Wang, et al. Unusual tripodal ligand Synthesis of 22-bis(diphenylphosphinomethyl)-l-phenylthio- propane and its group VI complexes. J. Organomet. Chern. 1989;376:333-342 (SCI).
  61. 張憲義, 王信二, 蔡瑞燦, 童永黔. 分析輻射源項之電腦程式探討. 台電核能月刊 1986;: (OI).
  62. H. E. Wang and Z. T. Tsai. MELCOR 110 and 150 Test calculations related to peach bottom plant TC2 Accident. INER-T1125 1986;: (OI).
  63. 王信二, 謝俊雄, 丁幹, 馬建宏, 朱樹恭. 放射性同位素工業應用-石化工業大型連續式氧化反應槽滯留時間之測定與攪拌效率評估. INER-T1000 1985;: (OI).
  64. 王信二, 謝俊雄, 蔡瑞燦, 林清科. 以乾餾法生產高比放射性強度碘-131之研究. INER-T0899 1983;: (OI).
研討會發表
  1. Mao-Chi Weng, Tien-Kuei Chang, Yi-Yu Lin, Jia-Je Li, Tian-Lu Cheng and Hsin-Ell Wang. Evaluation of anti-PEG gene mediated tumor imaging and therapy in a hepatocellular carcinoma-bearing mouse model. 2009 World Molecular Imaging Congress, September 23-26, Montreal, Canada
  2. Hao-Wen Kao, Chi-Jen Chan, Yuan-Chia Chang, Jui-Mei Lu, Shain-Jy Wang, Wuu-Jyh Lin and Hsin-Ell Wang. Evaluation of biodistribution and pharmacokinetics of micelles in a colon adenocarcinoma-bearing mouse model. 2009 World Molecular Imaging Congress, September 23-26, Montreal, Canada
  3. Hao-Wen Kao, Chi-Jen Chan, Sung-ching Chen, Shain-Jy Wang, Ming-Hsien Lin, Wuu-Jyh Lin, Jenn-Tzong Chen and Hsin-Ell Wang. Pharmacokinetic evaluation of radiolabelled hyaluronic acids: a potential agent for the early osteoarthritic therapy. 10th International Symposium on the Synthesis and Applications of Isotopes and Isotopically Labelled Compounds, June 14-18, Chicago, USA, 2009
  4. M.C. Weng, T.K. Chang, H.E. Wang. Evaluation of anti-PEG gene mediated tumor therapy after pegylated liposomal drugs treatment in a hepatocellular carcinoma-bearing mouse model. The 56th Annual Meeting of the Society of Nuclear Medicine, June 13-17, Toronto, Canada, 2009
  5. Wei-Ting Chang, Chun-Yi Wu, Pei-Chia Chan, Chih-Yuan Lin, Ren-Shyan Liu, Mian M Alauddin and Hsin-Ell Wang. Evaluation of 18F-FMAU as a PET Imaging Probe for Monitoring Tumor Treatment. The 56th Annual Meeting of the Society of Nuclear Medicine, June 13-17, Toronto, Canada, 2009
  6. Shih-Yen Wu, Tien-Kuei Chang, Jia-Wei Kou, Hsin-Ell Wang. Biological evaluation of 111In-DOTA-Annexin V for monitoring the HSV1-tk/GCVprodrug activation gene therapy. The 56th Annual Meeting of the Society of Nuclear Medicine, June 13-17, Toronto, Canada, 2009
  7. Chun-Yi Wu, Pei-Chia Chan, Wei-Ting Chang, Ren-Shyan Liu, Mian M. Alauddin and Hsin-Ell Wang , Radiosynthesis of F-18 labeled cytidine analogue 18F-FIAC,6th International Conference on Isotopes,Seoul, Korea,2008
  8. Chi-Wei Changa,, Chi-Jiun Peng, Mai Lin, Ren-Shyan Liu, Shyh-Jen Wang, Wuu-Jyh Lin, and Hsin-Ell Wang, The robotic radiosynthesis of 5-18F-fluoro-2'-deoxyuridine and its biological characterization,6th International Conference on Isotopes,Seoul, Korea,2008
  9. Chien-Chung Hsia, Cheng-Hsien Lin, PhD, Rong-Tsun Wu, PhD, Lie-Hang Shen, PhD, Haw-Jan Chen, PhD, Hsin-Ell Wang, PhD, The synthesis and biodistribution study of 99mTc-HL91-NI as an imaging agent for Hypoxia,6th International Conference on Isotopes,Seoul, Korea,2008
  10. Chien-Yien Ting, Hsin-Ell Wang, The study of CVD diamond films for air cavity dose estimation in radiotherapy,6th International Conference on Isotopes,Seoul, Korea,2008
  11. Y.C. Lu, J.J. Li, Y.Y. Lin, C.C. Chen, J.J. Hwang, G. Ting, H.E. Wang, Monitoring tumor growth in a Colon Carcinoma ascites mouse model by in vivo bioluminescence imaging,The 55th Annual Meeting of the Society of Nuclear Medicine,USA,2008
  12. C.Y. Wu, P.C. Chan, W.T. Chang, C.W. Chang, R.S. Liu, and H.E Wang, 18F-1-(2-deoxy-2-fluoro-β-D-arabinofuranosyl)-5-iodocytosine (18F-FIAC) as a novel HSV1-tk gene expression probe,The 55th Annual Meeting of the Society of Nuclear Medicine,USA,2008
  13. Hao-Wen Kao, Chi-Jen Chan, Sung-ching Chen, Shain-Jy Wang, Ren-Shen Liu, ,Shyh-Jen Wang., Wuu-Jyh Lin and Hsin-Ell Wang, Pharmacokinetic study of radiolabeled hyaluronic acid of different molecular weight in an osteoarthritis rabbit model,2008 world molecular imaging congress,France, Nice,2008
  14. Yi-Yu Lin, Jia-Je Li, Yi-Ching Lu, Mao-Chi Weng, Jeng-Jong Hwang, Yun-Long Tseng, Wuu-Jyh Lin, Gann Ting, Hsin-Ell Wang, Evaluation of therapeutic efficacy of pegylated 111In-VNB-liposomes in a C26/tk-luc colon carcinoma-bearing mouse model,2008 world molecular imaging congress,France, Nice,2008
  15. Pei-Chia Chan, Wei-Ting Chang, Chun-Yi Wu, Ren-Shyan Liu, Chi-Wei Chang and Hsin-Ell Wang, Preliminary study of 18F-clofarabine as a “pre-test” PET imaging probe for tumor treatment,2008 world molecular imaging congress,France, Nice,2008
  16. Hsin-Ell Wang, Pei-Chia Chan, Chun-Yi Wu, Wuu-Jyh Lin, Chi-Wei Chang and Ren-Shyan Liu., Evaluation of 18F-fluoroacetate as a PET probe in a mouse model bearing lung carcinoma and inflammation.,The 54th Annual Meeting of the Society of Nuclear Medicine,Washington DC, USA,2007
  17. Hsin-Ell Wang, Yi-Yu Lin, Jia-Je Li; Yi-Ching Lu, Jeng-Jong Hwang, Yun-Long Tseng, Chih-Hsien Chang and Gann Ting, Evaluation of pharmacokinetics of 111In-VNB-pegylated liposomes for cancer therapy in a colon carcinoma ascites mouse model,The 54th Annual Meeting of the Society of Nuclear Medicine,Washington DC, USA,2007
  18. Hsin-Ell Wang, Tian-Lu Cheng, Hung-Man Yu, Yu-Cheng Su, Hsin-Pei Yeh and Jia-Je Li., A novel imaging proprobe for monitoring prodrug-activating enzyme in vivo,The 54th Annual Meeting of the Society of Nuclear Medicine,Washington DC, USA,2007
  19. Ren-Shyan Liu, Chien-Feng Lin, Hsin-Ell Wang, Ya-Ju Hsieh and Gelovani, Juri G, Molecular Imaging of EGFR Kinase Activity in Lung Cancer Using Radioiodine-Labeled IPQA Morpholino Derivative,The 54th Annual Meeting of the Society of Nuclear Medicine,Washington DC, USA,2007
  20. Hsin-Pei Yeh, Jia-Je Li, Yu-Cheng Su, Tian-Lu Cheng, Hsin-Ell Wang, Molecular Imaging with 124/131I- Phenolphthalein Glucuronide for Monitoring Membrane-Anchored β-Glucuronidase Gene Expression,Joint Molecular Imaging Conference 2007,Rhode Island. USA,2007
  21. Chuan-Lin Chen, Hsin-Ell Wang, Wen-Yi Chang, Wei-Ting Chang, Ren-Shen Liu, Yi-Yu Lin, Pei-Chia Chan, A Novel Imaging Probe FIAC for Monitoring Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression,Joint Molecular Imaging Conference 2007,Rhode Island, USA,2007
  22. C.Y. Wu, P.C. Chan, W.T. Chang, C.W. Chang, R.S. Liu, and H.E Wang, A comparison study of FEAU, FIAU and FIAC as HSV1-tk gene expression probes,Proceedings of 2007 4th Taipei International Symposium of Molecular Imaging,Taipei, ROC,2007
  23. Yi-Ching Lu, Yi-Yu Lin, Jia-Je Li, Jeng-Jong Hwang, Gann Ting, Hsin-Ell Wang, Monitoring and evaluating tumor growth and ascites in a C26/tk-luc Colon Carcinoma ascites animal model by in vivo bioluminescence imaging,Proceedings of 2007 4th Taipei International Symposium of Molecular Imaging,Taipei, ROC,2007
  24. Hsin-Ell Wang, Ta-Kai Chou, Chih-Hsien Chang, Tsui-Jung Chang, Ren-Shyan Liu and Syh-Jen Wang., Evaluation of 18F-FMISO, 18F-FDG and 18F-FAc as PET probes in a mouse model bearing sarcoma and inflammatory lesion.,The 54th Annual Meeting of the Society of Nuclear Medicine,Washington DC, USA,2007
  25. Hsin-Ell Wang, Chi-Wei Chang, Syh-Jen Wang and Ren-Shyan Liu, A high yield robotic synthesis of 5-18F-fluoro-2?-deoxyuridine,The 54th Annual Meeting of the Society of Nuclear Medicine,Washington DC, USA,2007
  26. Hsin-Ell Wang, Chi-Jen Chan, Hao-Wen Kao, Shain-JyJ Wang, Jui-Mei M Lu and Yuan-Chia Chang, Evaluation of pharmacokinetics of micelles in a colon adenocarcinoma-bearing mouse model,The 54th Annual Meeting of the Society of Nuclear Medicine,Washington DC, USA,2007
  27. Hung-Man Yu, Chun-Yi Wu, Pei-Chia Chan, Kuo-Liang Chou, Chih-Hao Chen, Li-Shing Chu, Ren-Shen Liu and Hsin-Ell Wang., A comparative study of 18F-fluoroacetate, 11C-acetate, and 18F-FDG in tumor-bearing animal modals,The 52th Annual Meeting of the Society of Nuclear Medicine,,2005
  28. Hsin-Ell Wang, Chia-Hung Hsieh, Yu-Fang Chen, Hung-Man Yu, Jeng-Jong Hwang, Jyh-Cheng Chen, Ren-Shen Liu, Ji-Jung Kai and Fu-Du Chen., Evaluation of pharmacokinetics of 4-borono-2-18F-fluoro-L-phenylalanine-fructose for boron neutron capture therapy in a glioma-bearing rat model with hyperosmolar blood-brain barrier disruption.,The 52th Annual Meeting of the Society of Nuclear Medicine,,2005
  29. Steve R. Roffler, Hsin-Ell Wang, Hung-Man Yu, Wen-Da Chang, Chiu-Min Cheng, Yu-Ling Lu, Bing-Mae Chen and Tian-Lu Cheng., A membrane antibody receptor for noninvasive imaging of gene expression in vivo.,The 52th Annual Meeting of the Society of Nuclear Medicine,,2005
  30. Hsin-Ell Wang, Yi-Ching Lu, Ning-Ning Heish, Kuang-Liang Huang, Yun-Long Tseng, Jeng-Jong Hwang, Wuu-Jyh Lin, Shyh-Jen Wang, Gann Ting, Jacqueline Whang-Peng, Preparation and biological characterization of 111In-labeled pegylated liposomes for tumor targeting in a mice model,The 4th annual meeting of the Society for Molecular Imaing,Germany,2005
  31. Hung-Chun Kao, Kuo-Hung Wu, Chia-Jung Chang, Shih-Ying Lee, Yu-Ching Ni, Wei-Lun Hsu, Hsueh-Hsuan Liu, Hsin-Ell Wang, Chia-Chieh Chen, 123I-MIPP as a scintigraphic probe for norepinephrine transporter in a rat model,The 4th annual meeting of the Society for Molecular Imaing,Germany,2005
  32. C.H. Chang, S.Y. Wu, H.E. Wang, T.H. Tsai, T.W. Lee, K.H. Fan, S.R. Chang, R.S. Liu, Y.K. Fu, Evaluation of 18F-FET and 18F-FDG for differentiating lung carcinoma from inflammation in a mouse by MicroPET,The 4th annual meeting of the Society for Molecular Imaing,Germany,2005
  33. H. E. Wang, H. M. Yu, R. S. Liu, J. J. Hwang, K. H. Chi, F. D. Chen, S. Q. Liao and S. H. Yeh, Improve targeting of rat hepatoma by using I-125-iododeoxyuridine/lipiodol emulsion.,The 51th Annual Meeting of the Society of Nuclear Medicine,U.S,2004
  34. H. E. Wang, H. M. Yu, M. Lin, C. W. Chang, R. S. Liu, W. P. Deng, W. J. Lin, Y. K. Fu., A promising PET probe in the HSV-1-thymidine kinase gene therapy model.,The 51th Annual Meeting of the Society of Nuclear Medicine,U.S,2004
  35. H E Wang, S Y Wu, C W Chang, R S Liu, D Lee and J C Chen., A novel synthesis of O-(2-[F-18]fluoroethyl)-L-tyrosine and its biological evaluation in animal tumor models.,The 50th Annual Meeting of the Society of Nuclear Medicine,,2003
  36. H E Wang, S Y Wu, C W Chang, R S Liu, D Lee and J C Chen., A comparative study of F-18-labeled unnatural amino acids with [18F]FDG in the evaluation of brain tumor.,The 50th Annual Meeting of the Society of Nuclear Medicine,,2003v
  37. H. E. Wang, A. H. Liao, P. F. Chang, F. D. Chen, J. C. Chen, J. J. Hwang, H. M. Yu and R. S. Liu., Biological characterization of 4-borono-2-[18F]fluoro-l-phenylalanine-fructose in glioma-bearing rat model. 909-912,Research and Development in Neutron Capture Therapy,Essen, Germany,2002
  38. H. E. Wang, W. P. Deng, P. F. Chang, C. W. Chang, R. S. Liu, W. J. Lin and G. Ting., Evaluation and Comparison of 18F-FHBG and 131I-FIAU as gene probes in gene therapy.,The 49th Annual Meeting of the Society of Nuclear Medicine,,2002
  39. H. E. Wang, K. L. Hwang, H. Y. Yu, W. J. Lin, R. S. Liu and G. Ting., Cell nucleus-level tumor dosimetry of *IUdR in rat hepatoma tumor model, June 23-27, 2001,The 48th Annual Meeting of the Society of Nuclear Medicine,,2001
  40. H. E. Wang, W. P. Deng, C. J. Peng, Y. W. Wu, C. W. Chang, H. Y. Yu, R. S. Liu and W. J. Lin., Non-invasive gene probe in a HSV-1 thymidine kinase gene therapy model. June 23-27, 2001,The 48th Annual Meeting of the Society of Nuclear Medicine,,2001
  41. H. E. Wang, R. S. Liu, F. D. Chen, H. M. Yu, K. H. Chi, K. L. Huang, A. R. Lou, G. Ting, Improved targeting of radioiododeoxyuridine to rat hepatoma by use of lipiodol contrast medium.,The Annual Meeting of the Society of European Nuclear Medicine.,,2000
  42. H. E. Wang, R. S. Liu, F. D. Chen, H. M. Yu, K. H. Chi, K. L. Huang, A. R. Lou, G. Ting, Targeted Tumor Radiotherapy with Radioiododeoxyuridine In Lipiodol. December 14-19,The 2000 International Chemical Congress of Pacific Basin Societies.,,2000
  43. H. E. Wang, R. S. Liu, F. D. Chen, C. W. Chang, H. M. Lin, C. H. Lin and H. J. Chen., Biological characterization of three diastereomers of [F-18]4-fluoro-1-(2’-nitro-1’-imidazolyl)-2,3-dihydroxybutane as PET agents for tumor hypoxia evaluation .,The 46th Annual Meeting of the Society of Nuclear Medicine.,,1999
  44. Y. H. Ou, F. D. Chen, L. C. Huang, H. E. Wangand F. Q. H. Ngo, Cellular and biochemical effects of radiation.,生物醫學聯合學術年會,,1997
  45. S. K. Meegalia, Z. P. Zhuang, H. E. Wang and H. F. Kung, et al., Synthesis and binding studies of N-([2'-pyrrodidinyl]methyl)-2,3-dimethoxy-5-iodobenzamides as PET and SPECT imaging agents for dopamine D2 and D3 receptors.,The IXth International Symposium of Radiopharmaceutical Chemistry.,,1995
  46. M. H. Li and H. E. Wang, et al., Production and on-line quality control of 1-123-Nal capsule for thyroid function study. Society, No. 2. p32,The IXth Symposium of Chinese Nucl. Med.,,1995
  47. H. E. Wang, T. H. Wu, et al., The production and quality control of INER 1-123-Nal oral solution.,The IXth Symposium of Chinese Nucl. Med. Society, F2, p30,,1995
  48. H. E. Wang, K. L. Huang, L. H. Shen and H. T. Huang, The routine production of 1-123-OIH, a radiopharmaceutical for renal imaging.,The IXth Symposium of Chinese Nucl. Med. Society, No. 9, p34,,1995
  49. H. E. Wang, K. L. Huang, L. H. Shen and H. T. Huang, The preparation of p-iodophenyl fatty acid for myocardial imaging. (1) Labeling and purification of 1-123-IPPA,The IXth Symposium of Chinese Nucl. Med. Society, C5, p28,,1995
  50. S. P. Wey, M. S. Liaw, Y. L. Lai, H. E. Wang and K. L. Huang, Optimization of radioiodinated fatty acid formulation with rat mode.,The IXth Symposium of Chinese Nucl. Med. Society, B5, p26,,1995
  51. 王信二, 謝柏滄, 吳俊彥, 謝俊雄, 丁幹, 程序分離後鍶-90回收液再利用之探討, 119-AP-054, p271,中國化學會80年度年會,,1991
  52. 王信二, 沈力漢, 謝俊雄, 丁幹, 碘-125同位素及植體射源之研製,行政院原子能委員會七十六年度研究發展計劃成果討論會,,1987
  53. H. E. Wang, T. H. Hsieh, C. H. Ma and S. K. Chu, Determination of resident time of petrochemical reactors by using Br-82 tracer, Proceedings of International Symposium on Isotope Application,The Nuclear Energy Society, R. 0. C., pl29,,1986
  54. H. E. Wang, T. H. Hsieh, L. H. Shen and G. Ting, Preparation of carrier-free ioidne-125 solution by irradiation of high pressure  xenon gas, Proceedings of International Symposium on Isotope Application,The Nuclear Energy Society, R.O. C., p119-128,,1986natural