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系所資訊
陳傳霖 副教授

陳傳霖 副教授

有機化學博士

專長:有機合成、放射化學、有機金屬化學
辦公室:實驗大樓B330室
電話:(02)2826-7062(office) (02)2826-7000 #5591(lab)
電子信箱:clchen2@ym.edu.tw
諮詢時間:週三 13:30 ~ 15:30


 

研究興趣

  近幾年來分子影像(molecular imaging)已成為一個熱門的研究領域,其特性是利用非侵入方式探索在活體內的生物學以及生化反應的處理過程,以期得到與疾病診斷或治療上相關聯的資料。核子醫學影像(PET/SPECT)以及磁振造影(MRI)等分別屬於分子影像研究的重要領域。其中核子醫學影像需要合適的示蹤劑(radiotracer),而磁振造影有時也需要適當的對比劑(contrast agent)以提供較佳之影像結果。因此目前我們主要研究興趣在利用化學合成方式發展新型的核醫藥物,包括目前主要的包括中樞神經系統的受體的造影劑帕金森氏症、憂鬱症以及基因造影劑與磁振造影對比劑等。

進行中之研究計畫

  1. 針對腦部serotonin 5HT1A受體的造影劑[11C]-WAY100635, [18F]-FCWAY. [18F]-MPPF等藥物的合成及研究,進行中
  2. 基因造影劑 [18F]FEAU, [131I]FIAC,及其他新型藥物設計與合成研究,進行中

實驗室成員

碩士班 (入學年度)

  1. 孟凡傑-慈濟技術學院醫放系畢業(102)
  2. 高誌廷-中山醫學大學醫放系畢業(102)
  3. 詹振勳-中山醫學大學醫放系畢業(101)
  4. 林萬里-陽明大學醫放系畢業(101)
  5. 蘇哲緯-陽明大學醫放系畢業(100)

學術著作

期刊論文
  1. Rung-Yi Lai, Chuan-Lin Chen and Shiuh-Tzung Liu. In Situ Generated palladium nanoparticles for catalytic dehalogenation of Aryl halides and deborontion of Arylboronic acids. Journal of the Chinese Chemical Society 2006;(53):979-985 (SCI).(Impact factor: 0.643;Rank: 71.09%)
  2. Chi-Tsing Chang, Chuan-Lin Chen, Yi-Hong Liu, Shie-Ming Peng, Pi-Tai Chou, and Shiuh-Tzung Liu. Coordination of Fluoro ligands toward Sodium ions Make A differences: Aqua Sodium ions Act as Bronsted Acids in Polymerization of Vinyl ether and Styrenes. Inorganic Chemistry 2006;(45):7590-7592 (SCI).(Impact factor: 4.123;Rank: 9.30%)
  3. Chuan-Lin Chen, Yi-Hung Liu, Shie-Ming Peng and Shiuh-Tzung Liu. Air and Moisture Stable Cyclopalladated Complexes as Efficient Catalysts for Suzuki-Miyaura Coupling Reaction. Organometallics 2005;(24):1075-1081 (SCI).(Impact factor: 3.833;Rank: 13.95%)
  4. Chuan-Lin Chen, Yi-Hung Liu, Shie-Ming Peng and Shiuh-Tzung Liu. An efficient catalyst for Suzuki –Miyaura Coupling reaction in aqueous medium under aerobic conditions. TETRAHEDRON LETTERS 2005;(46):521-523 (SCI).(Impact factor: 2.615;Rank: 35.71%)
  5. Chuan-Lin Chen, Yi-Hung Liu, Shie-Ming Peng and Shiuh-Tzung Liu. Substituent effect on Cyclopalladation of Arylimines. JOURNAL OF ORGANOMETALLIC CHEMISTRY 2004;(689):1806-1815 (SCI).(Impact factor: 2.168;Rank: 27.91%)
研討會論文
  1. Wen-Yi Chang, Wei-Ti Kuo, Ren-Shyan Liu, Hsin-Ell Wang, Chuan-Lin Chen*, 10. Synthesis of Two [131I]-labeled Pyrimidine Nucleosides for Imaging Herpes Simplex Virus 1 Thymidine Kinase Gene Expression,Chinese Chemical Society Meeting,changhwa,2008
  2. Wei-Ti Kuo, Wen-Yi Chang, Ren-Shen Liu, Hsin-Ell Wang, Chuan-Lin Chen*, 11. Synthesis of Radioiodinated Nucleoside Analogues [131I]-FIAC and [131I ]-5-iodocytidine, as potential SPECT probes for Imaging HSV1-tk Gene Expression,Chinese Chemical Society Meeting,Changhwa,2008
  3. Wen-Yi Chang, Wei-Ti Kuo , Ren-Shyan Liu, Hsin-Ell Wang, Chuan-Lin Chen *, 9. Synthesis of [131I ]-5-iodocytidine and 5-(2-iodoethynyl)-2’-fluoro-2’-deoxyarabinouridine ([131I]-FIEAU) and Their Biological Evaluation with [131I]-FIAC as Probes for monitoring HSV1-tk Gene Expression,5th Taiwanese Society for Molecular Imaging Conference,Taichung,2008
  4. Chuan-Lin Chen, Hsin-Ell Wang, Wen-Yi Chang, Wei-Ting Chang, Ren-Shen Liu, Yi-Yu Lin, Pei-Chia Chan, A Novel Imaging Probe FIAC for monitoring Herpes Simplex Virus Type 1 Thymidine Kinase Gene Expression, p148,Joint Molecular Imaging Conference,Rhode Island, USA,2007
  5. Chuan-Lin Chen*, Wen-Yi Chang, Wei-Ting Chang, Ren-Shen Liu, Yi-Yu Lin, Pei-Chia Chan and Hsin-Ell Wang, 8. Synthesis of 2’-deoxy-2’-fluoro-5-[131I]-Iodo-1-β-D-arabinofuranosyl-cytosine and Their Biological Evaluation as Probe for HSV1-tk Gene Expression.,4th Taiwanese Society for Molecular Imaging conference,Taipei,2007
  6. Chuan-Lin Chen, Yi-Hung Liu, Shie-Ming Peng, Shiuh-Tzung Liu*, Ligand effect on Air Stable, Highly Active Palladacyclic Catalysts for Suzuki-Miyaura Coupling Reaction.,14th International Symposium on Homogeneous Catalysis - ISHC-14,Munich, Germany,2004
  7. Chen-Yen Hung, Chuan-Lin Chen, Shiuh-Tzung Liu*, Air Stable, Highly Active Palladacyclic Catalysts for Carboxylation and Amidation of Aryl Iodides.,Chinese Chemical Society Meeting,,Taichung, Taiwan.,2004
  8. Chuan-Lin Chen, Yi-Hung Liu, Shie-Ming Peng, Shiuh-Tzung Liu*, Ligand effect on Suzuki Coupling Reaction Cyclopalladation of Substituted Arylimines.,Chinese Chemical Society Meeting,Taoyuan, Taiwan,2003
  9. Shiuh-Tzung Liu*, Chuan-Lin Chen, Yi-Hung Liu, Shie-Ming Peng; Abtracts of Papers,, Ligand effect on Suzuki Coupling Reaction.,226th ACS National Meeting,New York, US.,2003
  10. Chuan-Lin Chen, Yi-Hung Liu, Shie-Ming Peng, Shiuh-Tzung Liu*, Substituent effect on Cyclopalladation of Arylimine Ligands.,The 4th International Symposium for Chinese Inorganic Chemists,Hsinchu, Taiwan,2002
  11. Chuan-Lin Chen, Yi-Hung Liu, Shie-Ming Peng, Shiuh-Tzung Liu*, Synthesis Substituted N-benzylideneamines Cyclopalladated Complexes.,Chinese Chemical Society Meeting,Taipei, Taiwan.,2002