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系所資訊
葉信顯 專案助理教授

葉信顯 醫學博士

轉譯醫學影像實驗室


國立陽明大學 腦科學中心 助理研究員
國立陽明大學 生物醫學影像暨放射科學系 兼任助理教授
國立陽明大學 生醫光電暨分子影像研究中心成員


英國曼徹斯特大學 轉譯醫學所 影像科學學程 醫學博士(2012年8月起更名為人口健康所)
博士學程由英國曼徹斯特大學之渥夫森分子影像中心與美國休士頓安德森癌症中心之研究診斷影像部門共同指導


Skye Hsin-Hsien Yeh, Ph.D., Assistant Professor
Translational Imaging lab

Assistant Research Fellow, Brain Research Center, National Yang-Ming University.
Adjunct Assistant Professor, Department of Biomedical Imaging and Radiological Sciences, National Yang-Ming University.
Biophotonic and Molecular Imaging Research Center, National Yang-Ming University.


University of Manchester, Institute of Translational Medicine, Imaging Sciences Centre (programme changed to Population Health from 1 August 2012).
Doctoral Program was under supervision of Wolfson Molecular Imaging Centre (WMIC), The University of Manchester, United Kingdom and Department of Experimental Diagnostic Imaging, MD Anderson Cancer Center, United State.

Office address: Research Building, Room 131-2
Email:hhyeh@ym.edu.tw
TEL:02-2826-7000 Ext.5892
Student consulting hour: Thursday 14:00-16:00
Personal website: http://www.ym.edu.tw/~hhyeh


 

證照

醫事放射師

License

Medical Radiologic Technologist

研究興趣

分子癌症影像、腦神經影像、影像導引式治療藥物篩選、多重影像模組藥物動力學、放射藥物研發之轉譯醫學
研究內容為利用新興正子造影劑評估其在癌症與神經系統疾病的適用性。所應用的影像評估系統包括幾個核心技術,如細胞攝取,細胞結合試驗,動物組織萃取,數位式放射顯影法,動態藥物藥效學與多重影像擷取與比較(PET, SPECT,Optical image,CT and MRI)。本研究團隊將高階影像技術與分析方法應用於數種癌症動物模式或神經退化性疾病之基因鼠;藉此開發新型影像診斷造影劑或是應用活體影像高效率篩選開發中或老藥新用之治療藥物成效。


Research Interests

Molecular imaging, Nuroimaging, Translational Radiopharmaceutical Sciences
The research activities in our lab include molecular PET imaging of cancer and the central nervous system using newly developed radiotracers. Experimental imaging system consists of several different core technique including in vitro cell uptake, reversible or irreversible binding, tissue extraction, digital autoradiography, dynamic analysis of metabolites and pharmacokinetics/ pharmacodynamics and includes different imaging modalities such as PET, SPECT,Optical image, CT and MRI. Our laboratory has developed and produced clinically relevant animal models of various CNS diseases and cancers including transgenic and disease models for testing new imaging and therapeutic approaches in which the efficacy of imaging of a given therapeutic strategy will be evaluated.

Honors and Awards

  1. Travel Award, 2013
    World Molecular Imaging Congress in Savannah, Georgia USA
  2. Selected Abstracts for Highlight Lecture, 2012
     World Molecular Imaging Congress in Dublin, Ireland.
    • PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for quantification of HDAC class II expression-activity in the brain of non-human primates.
    • Quantification of Suberoylanilide Hydroxamic Acid, Valproic Acid and Class II-specific HDAC Inhibitor-Induced Inhibiton of HDAC activity in the Rat Brain using In Vivo PET/CT Imaging with HDAC Class IIa-Specific Radiotracer.
  3. Performance Award, 2011
    Department of Experimental Diagnostic Imaging, MD Anderson Cancer Center, Texas USA. Outstanding Performance in Imaging Science
  4. Student Travel Award, 2011
    World Molecular Imaging Congress in San Diego USA
  5. Student Travel Award, 2010
    World Molecular Imaging Congress in Kyoto Japan
  6. Performance Award, 2009
    Department of Experimental Diagnostic Imaging, MD Anderson Cancer Center, Texas USA. Outstanding Performance in Imaging Science
  7. Overseas Research Students Award, 2009-2012
    University of Manchester, UK. Worldwide Competition of Dissertation Fellowship for International Students
  8. Performance Award 2008
    Department of Experimental Diagnostic Imaging, MD Anderson Cancer Center, Texas USA. Outstanding Performance in Imaging Science
  9. Student Travel Award, 2008
    World Molecular Imaging Congress in Nice, France
  10. Graduate Scholarship, 2005-2008
    The University of Texas Graduate School of Biomedical Sciences, MD Anderson Cancer Center, Texas USA
  11. The Best Annual Investigation, 2001
    Institute of Nuclear Energy Research, Taoyuan Taiwan Title:Biodistribution Study of [123I] ADAM in Mice: correlate to whole body autoradiography. (Grant 902001INER010)

Current activity

  • Neurodegenerative disease: Alzheimer's disease (AD) and Huntington’s Disease (HD)
  • Psychiatric disease: Post-traumatic stress disorder (PTSD)
  • Oncology: non small cell carcinoma lung cancer

Publications

Book chapter
  • Skye Hsin-Hsien Yeh, Chun-Kai Fang, Jeng-Jomg Hwang. Effects of Club Drugs on Dopaminergic and Serotonergic Systems: Use of [18F]FDOPA, [99mTc]TRODAT-1 and [I*]ADAM. The Neuropathology Of Drug Addictions And Substance Misuse, Kings College London (in press)
Peer-Reviewed Original Research Articles
  1. Hui-Ching Lin, Cheng-Ta Li, David Tat-Wei Tan, Chi-Wei Cheng, Ta-Kai Chou, Fan-Lin Kong, Tsung-Hsun Yu, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu, Skye Hsin-Hsien Yeh*. Non-linear alteration of serotonin transport availability in posttraumatic stress disorder measured with 4-[18F]ADAM positron emission tomography. Current Molecular Imaging. 2015 Nov. DOI: 10.2174/2211555204 666151014224015
  2. Bonomi R, Mukhopadhyay U, Shavrin A, Yeh HH, Majhi A, Dewage SW, Najjar A, Lu X, Cisneros GA, Tong WP, Alauddin MM, Liu RS, Mangner TJ, Turkman N, Gelovani JG. Novel Histone Deacetylase Class IIa Selective Substrate Radiotracers for PET Imaging of Epigenetic Regulation in the Brain. PLoS One. 2015 Aug 5;10(8):e0133512. (IF:3.53, R=8/56=14%)
  3. Chi-Wen Yeh, Skye Hsin-Hsien Yeh, Feng-Shiun Shie, Wen-Sung Lai, Hui-Kang Liu, Tsai-Teng Tzeng, Huey-Jen Tsay and Young-Ji Shiao. Impaired cognition and cerebral glucose regulation are associated with astrocyte activation in the parenchyma of metabolically stressed APPswe/PS1dE9 mice. Neurobiol Aging. 2015 Jul 18. pii: S0197-4580(15)00382-6. (IF:5.013 ,Ranking:16%).
  4. Whitehouse A, Doherty K, Yeh HH, Robinson AC, Rollinson S, Pickering-Brown S, Snowden J, Thompson JC, Davidson YS, Mann DM.Histone deacetylases (HDACs) in Frontotemporal Lobar Degeneration. Neuropathol Appl Neurobiol 2014 May 27. doi: 10.1111/nan.12153. [Epub ahead of print] (Impact factor: 4.873; Rank:45/255, 17.85%)
  5. Skye Hsin-Hsien Yeh, Ming-Hsien Lin, Fan-Lin Kong, Chi-Wei Chang, Li-Chung Hwang, Chien-Feng Lin, Jeng-Jong Hwang, Ren-Shyan Liu. Evaluation of inhibitory effect of recreational drugs on dopaminergic terminal neuron by PET and whole-body autoradiography. Biomed Res Int. 2014;2014:157923. http://dx.doi.org/10.1155/2014/157923 (Impact factor: 2.880; Rank: 50/159, 31.04%)
  6. Ya-Ju Hsieh, Luen Hwu, Chien-Chih Ke, Skye Hsin-Hsien Yeh, Chien-Feng Lin, Fu-Du Chen, Hsin-Ell Wang, Kang-Ping Lin, Ran-Chou Chen and R. Liu. Rational Design of a Triple Reporter Gene for Multimodality Molecular Imaging. Biomed Res Int. 2014;2014:605358. doi: 10.1155/2014/605358. Epub 2014 Apr 7. (Impact factor: 2.880; Rank: 50/159, 31.04%)
  7. Hsieh YJ, Hwu L, Chen YC, Ke CC, Chen FD, Wang HE, Lin KP, Yeh HH, Chang CW, Liu RS.. 21-Driven Multifusion Gene System for Evaluating the Efficacy of Histone Deacetylase Inhibitors by In Vivo Molecular Imaging and for Transcription Targeting Therapy of Cancer Mediated by Histone Deacetylase Inhibitor. J Nucl Med. 2014 Mar 17. [Epub ahead of print]. (SCI) (Impact factor: 7.022, Ranking: 0.9%)
  8. Skye Hsin-Hsien Yeh, Chien-Feng Lin, Fan-Lin Kong,Hsin-Ell Wang, Ya-Ju Hsieh, Juri G. Gelovani, Ren-Shyan Liu, Molecular Imaging of Nonsmall Cell Lung Carcinomas Expressing Active Mutant EGFR Kinase Using PET with [124I]-Morpholino-IPQA BioMed Research International, 2013.
  9. doi:10.1155/2013/549359. (SCI) (Impact factor: 2.880; Rank: 50/159, 31.04%)
  10. Hsin-Hsien Yeh, Daniel Young, Juri Gelovani Karl Herholz, David Mann. Histone deacetylase (HDAC) class II immunohistochemistry in human brains with Huntington’s disease. Brain Res. 2013 Apr 4;1504:16-24. doi: 10.1016/j.brainres. 2013.02.012. Epub 2013 Feb 16. (SCI) (Impact factor: 2.892; Rank: 126/251, 50.02%)
  11. Hsin-Hsien Yeh, Rainer Hinz, Suren Soghomonyan, Julius A. Balatoni, Uday Mukhopadhyay, Leo G. Flores, Asutosh Pal, Daniel Young, Hwan Jeong, Rajesh Uthamanthil, James Jackson, William Tong, Mei Tian, Mian M. Alauddin, Karl Herholz, Juri G. Gelovani. Quantification of HDAC activity in the forebrain, N.accumbens, and cerebellum in non-human primates using [18F]FAHA PET/CT and an optimized pharmacokinetic model. Neuroimage. 2013 Jan 1;64:630-9. doi: 10.1016/j.neuroimage.2012.09.019. Epub 2012 Sep 17. (SCI) (Impact factor: 6.252, Ranking: 3/116, 2.6%)
  12. Flores LG 2nd, Yeh HH, Soghomonyan S, Young D, Bankson J, Hu Q, Alauddin M, Huff V, Gelovani JG. Monitoring Therapy with MEK Inhibitor U0126 in a Novel Wilms Tumor Model in Wt1 Knockout Igf2 Transgenic Mice Using [18F]-FDG PET with Dual-Contrast Enhanced CT and MRI: Early Metabolic Response Without Inhibition of Tumor Growth. Mol Imaging Biol. 2013 Apr;15(2):175-85. doi: 10.1007/s11307-012-0588-5. (SCI) (Impact factor: 3.844, Ranking: 12.1%)
  13. Nashaat Turkman, Aleksander Shavrin, Vincenzo Paolillo, Hsin Hsien Yeh, Leo Flores, Suren Soghomonian, Brian Rabinovich, Andrei Volgin, Juri Gelovani, Mian Alauddin Synthesis and preliminary evaluation of [(18)F]-labeled 2-oxoquinoline derivatives for PET imaging of cannabinoid CB(2) receptor. Nucl Med Biol 2012, 39(4):593-600. (SCI) (Impact factor: 2.62, Ranking: 29.4%)
  14. Paolillo V, Yeh H H, Mukhopadhyay U, Gelovani JG, Alauddin MM. Improved detection and measurement of low levels of [18F]fluoride metabolized from [18F]-labeled pyrimidine nucleoside analogues in biological samples. 2011 Nucl Med Biol. Nov;38(8):1129-34. (SCI) (Impact factor: 2.62, Ranking: 29.4%)
  15. Schwartz DL, Bankson J, Nishii R, Bidaut L, Yeh HH, He Y, Williams R, Volgin A, Lemos R, Titai-Kumar A, Oh J, Soghomonyan S, Mukhopadhyay, Allaudin M, Mushkudiani I, Kuno N, Krishnan S, Bornmann W, Lai SY, Powis G, Hazle J, Gelovani JG. HIF-1 dependent stromal adaptation to ischemia mediates in vivo tumor radiation resistance. 2010 Mol Cancer Res 2011 Mar;9(3):259-70. (SCI) (Impact factor: 2.620, Ranking: 23.0%)
  16. Yeh HH, Ogawa K, Balatoni J, Mukhapadhyay U, Pal A, Gonzalez-Lepera C, Shavrin A, Soghomonyan S, Flores L, Young D, Volgin AY, Najjar AM, Krasnykh V, Tong W, Alauddin MM, Gelovani JG. Molecular Imaging of Active Mutant L858R EGFR Kinase Expressing Non Small Cell Lung Carcinomas using PET/CT with [18F]F-PEG6-IPQA. 2011 Proc Natl Acad Sci USA, 108(4):1603-8. Epub 2011 Jan 10. (SCI) (Impact factor: 9.771, Ranking: 5.1%)
  17. Ying Y, Ghosh P, Guo L, Pal A, Mukhapadhyay U, Peng Z, Yeh HH, Bertolini S, Flores LG, Young D, Volgin A, Soghomonyan S, Bornmann W, Logsdon C, Alauddin MM, Gelovani JG. Synthesis and Ex Vivo Autoradiographic Evaluation of Ethyl-beta-D:-galactopyranosyl-(1,4')-2'-deoxy-2'-[(18)F]fluoro-beta-D:-gluco- pyranoside A Novel Radioligand for Lactose-Binding Protein: Implications for Early Detection of Pancreatic Carcinomas with PET. 2010 Mol Imaging Biol Jun;13(3):536-46. (SCI) (Impact factor: 3.844, Ranking: 12.1%)
  18. Leo Garcia Flores, Susanna Bertolini, Hsin Hsin Yeh, Danel Young, Uday Mukhapadhyay, Ashutosh Pal, Yunming Ying, Andrei Volgin, Aleksandr Shavrin, Suren Soghomonyan,William Tong, William Bornmann, Mian M. Alauddin, Craig Logsdon, and Juri G. Gelovani. Detection of pancreatic carcinomas by imaging lactose-binding protein expression in peritumoral pancreas using [18F]fluoroethyl-deoxylactose PET/CT. 2009 PLoS One 4(11):e7977. (SCI) (Impact factor: 4.411, Ranking: 13.9%)
  19. Uday Mukhopadhyay, Suren Soghomonyan, Hsin Hsien Yeh, Leo G. Flores, Aleksandr Shavrin, Andrei Y. Volgin, Juri G. Gelovani, Mian M. Alauddin. N3-Substituted thymidine analogues: V. Synthesis and preliminary PET imaging of N3-[18F]fluoroethyl thymidine and 5 N3-[18F]fluoropropyl thymidine. 2008 Nucl Med Biol 35(6):697-705. (SCI) (Impact factor: 2.62, Ranking: 29.4%)
  20. Lin KJ, Yen TC, Wey SP, Hwang JJ, Ye XX, KY, Ting, Chen JC. Characterization of the binding sites of [123I]ADAM and the relationship to serotonin transporter in rat and mouse brains using quantitative autoradiography. 2004 J Nucl Med. 45, 673-681. (SCI) (Impact factor: 7.022, Ranking: 0.9%)
  21. Ye XX, Hwang JJ, Shieh JF, JC Chen, YT Chou, KY Tu, Wey SP, Ting G. In Vivo Quantification of bound [123I]ADAM to Serotonin Transporters in the Brains of Rabbits by SPECT. 2004 Nucl Med Biol. 31(8):995-1003. (SCI) (Impact factor: 2.62, Ranking: 29.4%)
  22. Ye XX, JC Chen, Liu RS, Wey SP, Lee JS, Ting G, Hwang JJ. Microautoraduography of [123I]ADAM in Mice Treated with Fluoxetine and Serotonin Reuptake Inhibitors. 2004 Nucl Med Bio. 31, 557-562. (SCI) (Impact factor: 2.62, Ranking: 29.4%)
  23. Lin KJ, Ye XX, Yen TC, Wey SP, Tzen KY, Ting G, Hwang JJ. Biodistribution study of [123I]ADAM in mice: correlation with whole body autoradiography. 2002 Nucl Med Biol. 29, 643-650. (SCI) (Impact factor: 2.62, Ranking: 29.4%)


Abstracts


  1. Skye Hsin-Hsien Yeh, Jin-Cai Chen, Zuo-Hao Tang, Hui-Jing Lin, Cheng-Ta Li3, Ta-Kai Chou, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu. PET/CT with [18F]ADAM using a biomarker for quantification of SERT change in the brain of PTSD rat model. (Oral presentation) 2013 World Molecular Imaging Congress, Savannah, Georgia.
  2. Yu-Ning Tang, Skye Hsin-Hsien Yeh, Jin-Cai Chen, Chin-Wei Cheng, Hsin-Ell Wang, Irene Han-Juo Cheng, Ren-Shyan Liu. Longitudinal coupled-imaging Alzheimer's disease mouse model using [11C]PIB and [18F]FDG PET.(Poster presentation) 2013 World Molecular Imaging Congress, Savannah, Georgia.
  3. Skye Hsin-Hsien Yeh, Jin-Cai Chen, Zuo-Hao Tang, Hui-Jing Lin, Cheng-Ta Li3, Ta-Kai Chou, Wen-Sheng Huang, Dong-Ping Su, Ren-Shyan Liu. PET/CT with [18F]ADAM using a biomarker for quantification of SERT change in the brain of PTSD rat model. (Poster presentation) 2013 Society of Nuclear Medicine and Molecular Imaging, Vancouver, BC, Canada.
  4. Yu-Ning Tang, Skye Hsin-Hsien Yeh, Jin-Cai Chen, Chin-Wei Cheng, Hsin-Ell Wang, Irene Han-Juo Cheng, Ren-Shyan Liu. Longitudinal coupled-imaging Alzheimer's disease mouse model using [11C]PIB and [18F]FDG PET. (Poster presentation) 2013 Society of Nuclear Medicine and Molecular Imaging, Vancouver, BC, Canada.
  5. Hsin-Hsien Yeh, Mei Tian, Leo G. Flores, Daniel Young, Vincenzo Paolillo, Kun-eek Kil, Uday Mukhopadhyay, Julius A. Balatoni, Suren Soghomonyan, Asutosh Pal, Rajesh Uthamanthil, James Jackson, WilliamTong, Daniel Young, Mian M Alauddin, Juri G. Gelovani. PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for Quantification of HDAC class II expression –activity in the brain in non-human primates (Oral presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland.
  6. HsinHsienYeh, LeoG.Flores II, Suren Soghomonyan, Kuneek Kil,Vincenzo Paolillo, Uday Mukhopadhyay, Julius Balatoni, Asutosh Pal,Aleksandr Shavrin, Daniel Young, Mian Alauddin, William Tong, Juri G. Gelovani. Quantification of Suberoylanilide Hydroxamic and Valproic Acid-Induced Inhibition of HDAC Activity in Rat Brain using In Vivo PET/CT Imaging with HDAC Class IIa-Specific Radiotracers. (Oral presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland.
  7. Hsin-hsien Yeh, Leo G. Flores, Daniel Young, Patrick J. Gillespie, Uday Mukhopadhyay, Asutosh Pal, Hwan Jeong, Nobuyoshi Fukumitsu, William Tong, Mian M Alauddin, Juri G. Gelovani. PET Imaging of Epigentic Mediated by HDACs in a Transgenic Mouse Model of Huntington’s Disease (Poster presentation) 2012 World Molecular Imaging Congress, Dublin, Ireland.
  8. Hsin-Hsien Yeh, Mei Tian, Leo G. Flores, Daniel Young, Vincenzo Paolillo, Kun-eek Kil, Uday Mukhopadhyay, Julius A. Balatoni, Suren Soghomonyan, Asutosh Pal, Rajesh Uthamanthil, James Jackson, WilliamTong, Daniel Young, Mian M Alauddin, Juri G. Gelovani. PET/CT/MRI with [18F]TFAHA using an optimized pharmacokinetic model for Quantification of HDAC class II expression –activity in the brain in non-human primates (Oral presentation) 2011 World Molecular Imaging Congress, San Diego USA.
  9. Hsin-hsien Yeh, Leo G. Flores, Daniel Young, Patrick J. Gillespie, Uday Mukhopadhyay, Asutosh Pal, Hwan Jeong, Nobuyoshi Fukumitsu, William Tong, Mian M Alauddin, Juri G. Gelovani. PET Imaging of Epigentic Mediated by HDACs in a Transgenic Mouse Model of Huntington’s Disease (Oral presentation) 2011 World Molecular Imaging Congress, San Diego USA.
  10. HsinHsienYeh, Leo G. Flores II, Suren Soghomonyan, Kuneek Kil,VincenzoPaolillo,Uday Mukhopadhyay, Julius Balatoni, AsutoshPal, Aleksandr Shavrin, DanielYoung, Mian Alauddin,William Tong, JuriG. Gelovani. Quantification of Suberoylanilide Hydroxamic and Valproic Acid-Induced Inhibition of HDAC Activity in Rat Brain using In Vivo PET/CT Imaging with HDAC Class IIa-Specific Radiotracers. (Poster presentation) 2012 World Molecular Imaging Congress, San Diego USA.
  11. Hsin-Hsien Yeh, Leo G. Flores II, Kun-eek Kil, Vincenzo Paolillo, Uday Mukhopadhyay, Julius Balatoni, Suren Soghomonyan, Aleksander Shavrin, Daniel Young, Mian Alauddin, William Tong, Juri G. Gelovani. Imaging epigenetic regulation in the rat brain mediated by HDACs class IIa Enzymes using PET/CT with 18F-TFAHA and 18F-DFAHA (Poster presentation) 2011 World Molecular Imaging Congress, San Diego USA.
  12. Hsin-Hsien Yeh, Rainer Hinz, Suren Soghomonyan, Julius A. Balatoni, Uday Mukhopadhyay, Leo G. Flores, Asutosh Pal, Hwan Jeong, Rajesh Uthamanthil, James Jackson, William Tong, Mei Tian, Mian M. Alauddin, Karl Herholz, Juri G. Gelovani. Quantification of HDAC activity in the forebrain, N.accumbens, and cerebellum in non-human primates using [18F]FAHA PET/CT and an optimized pharmacokinetic model. (Oral presentation) 2010 World Molecular Imaging Congress, Kyoto Japan.
  13. N. Fukumitsu, H. Yeh, L.G. Flores, S. Soghomonyan, U. Mukhopadhyay, D. Young, M.M. Alauddin, W. Tong, J.G. Gelovani. The Role of HDAC Activation in Chemotherapy-Induced Neurotoxicity and Protective Effects of HDAC Inhibitors in Rats Demonstrated using PET/CT with 18 F-FAHA and 18F-FDG (Oral presentation) 2010 World Molecular Imaging Congress, Kyoto Japan.
  14. Leo Garcia Flores, HsinHsien Yeh et. al., A Novel Model of Renal Tumor in Transgenic Mice: Characterization with Repetitive 18FDG PET and Dual Contrast-Enhanced CT Imaging. (Poster presentation) 2010 World Molecular Imaging Congress, Kyoto Japan.
  15. JJ Jong, HH Yeh et, al., Multi-Tracer Molecular-Genetic Imaging Reveals Distinct Areas of Coupling and Uncoupling of Blood Flow and HIF1 Signaling in a Rat Brain Glioma Model. (Poster presentation) 2010 World Molecular Imaging Congress, Kyoto Japan.
  16. Hsin Hsien Yeh, Suren Soghomonyan, Uday Mukhapadhya, Daniel Young, Leo G. Flores, Asutosh Pal, Kazuma Ogawa, Mian Alauddin, Raymond Gibson, Willian Tong, Juri G. Gelovani. Assessment of SAHA-induced Dose-Dependent Inhibition of HDACs Activity in the Rat Brain using In Vivo PET Imaging with 18FAHA. (Oral presentation) 2008 World Molecular Imaging Congress, France Nice.
  17. Hsin-Hsien Yeh, Daniel Young, Raymond Gibson, William Tong, Juri G. Gelovani. (2008) Imaging Expression-Activity of HDACs in the Awake Rat Brain using Autoradiography with [14C]AHA as a Prototype for [11C]AHA and PET. 2008 World Molecular Imaging Congress, France Nice.
  18. Hsin-Hsien Yeh, Suren Soghomonyan, Uday Mukhapadhyay, Daniel Young, Leo G. Flores, Asutosh Pal, Kazuma Ogawa, Raymond Gibson, Thomas Miller, Mian Alauddin, William Tong, Juri G.Gelovani. Determination of Dose-Dependent Inhibition of HDACs Activity induced by para-Fluoro-SAHA in the Rat Brain using In Vivo PET Imaging with [18F]FAHA. 2008 World Molecular Imaging Congress, France Nice.
  19. HsinHsien Yeh, Suren Soghomonyan, Uday Mukhapadhayay, Daniel Young, Leo G. Flores,Asutosh Pal, Kazuma Ogawa, Raymond Gibson, Mian Alauddin, William Tong, Juri G. Gelovani. Quantification of Valporic Acid-induced Dose-Dependent Inhibition of HDACs Activity in the Rat Brain using In Vivo PET Imaging with 18FAHA. 2008 World Molecular Imaging Congress, France Nice.
  20. Hsin Hsien Yeh, Ryuichi Nishii, Julius Balatoni, Asutosh Pal, Suren Soghomonyan, Leo Flores1, Andrei Volgin, Daniel Yang, Juri G. Gelovani. (2008) PET with [124I]I-PEG6-IPQA for Imaging Expression-Activity and Mutational Status of EGFR in Four Different Non Small Cell Carcinoma Xenografts in Mice. 2008 World Molecular Imaging Congress, France Nice.
  21. Hsin Hsien Yeh, Asutosh Pal, Julius Balatoni, Kazuma Ogawa, Leo Flores, Andrei Volgin, Daniel Yang, Juri G. Gelovani.Imaging Expression-Activity and Mutational Status of EGFR in Intracerebral Glioma Xenografts in Mice with [124I]I-PEG6-IPQA and PET. 2008 World Molecular Imaging Congress, France Nice.
  22. Hsin Hsien Yeh, Kazuma Ogawa, Julius Balatoni, Uday Mukhapadhyay, Asutosh Pal, Daniel Yang, Andrei Volgin, Mian Alauddin, Juri G. Gelovani. Imaging the Expression-Activity and Mutational Status of EGFR in Four Different Non Small Cell Carcinoma Xenografts in Mice using PET with [18F]F-PEG6-IPQA. . (oral presentation) 2008 World Molecular Imaging Congress, France Nice.
  23. U. Mukhopadhyay, S. Soghomonyan, A. Y. Volgin, H. H. Yeh, L. G Flores, J. G. Gelovani and M. M. Alauddin. Synthesis and preliminary PET imaging of N3-[18F]fluoroethyl thymidine and N3-[18F]fluoropropyl thymidine. 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA.
  24. Ryuichi Nishii, Uday Mukhopadhyay, Hsin Yeh, Suren Soghomonyan, Andrei Volgin, Mian Alauddin, William Tong, Juri Gelovani. PET imaging of histone deacetylase activity in a rat brain using 6-([18F]-fluoroacetamide)-1-hexanoicanilide ([18F]-FAHA). 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA
  25. Ryuichi Nishii, Uday Mukhopadhyay, Hsin Yeh, Suren Soghomonyan, Andrei Volgin, Mian Alauddin, William Tong, Juri Gelovani. 2007 Non-invasive imaging of histone deacetylase activity in human breast carcinoma xenografts in rats using positron emission tomography (PET) with [18F]-FAHA. 2007 Joint Molecular Imaging Conference, Providence, Rhode Island, USA
  26. David Schwartz, Sunil Krishnan, Norihito Kuno, Ioseb Mushkudiani, Andrei Volgin, Hsin Hsien Yeh, Yi He, Suren Soghomonyan, Uday Mukhopadhyay, Mian Alauddin, Shujun Shentu, Garth Powis, Juri Gelovani Molecular-Genetic In Vitro and In Vivo Imaging of HIF-1 Signaling Response to Radiation and Targeted Inhibition. 2006 Joint Molecular Imaging Conference, Hilton Waikoloa Village on the Big Island of Hawaii
  27. Ryuchi Nishii, Asutosh Pal, Suren Soghomonyan, Julius Balatoni, Ioseb Mushkudiani, Hsin Hsien Yeh, Uday Mukhopadhyay, Andrei Volgin, Aleksander Shavrin, David Maxwell, William Tong, Mian Alauddin, William Bornmann, Juri Gelovani Molecular Imaging of Different EGFR Kinase Mutant NSCL Carcinomas with [124I]-Mipqa PET for Prediction of Responsiveness to EGFR Kinase Inhib. 2006 Joint Molecular Imaging Conference, Hilton Waikoloa Village on the Big Island of Hawaii .
  28. Ye XX, Hwang JJ, Chen JC, Shieh JF, YT Chou. SPECT Imaging of Serotonin Transporters in the Brains of Rabbits by [123I]ADAM. 2003 Annual Meeting of the Society of Nuclear Medicine, New Orleans, USA.
  29. Ye XX, Hwang JJ, Hsieh JF, Chen JC. In Vivo quantification of bound [123I]ADAM in serotonin transporters in the brains of rabbits by SPECT. (oral presentation) 2002 Annual Meeting of the Society of Nuclear Medicine, Los Angles, USA.
  30. Lin KJ, Ye XX, Yen TC, et al. Biodistribution study of [123I]ADAM in mice: correlation to whole body autoradiography. 2002 Annual Meeting of the Society of Nuclear Medicine, Los Angeles, USA.
  31. Ye XX, Hwang JJ, Chen JC, Shieh JF. In Vivo quantification of bound 123I-ADAM in serotonin transporters in rabbit by SPECT. 2001 Annual Meeting of the Society of Nuclear Medicine, Taipei, Taiwan.
  32. Lin KJ, Yen TC, Ye XX, et al. The biodistribution of I-123 ADAM in mouse with macroautoradiography. 2001 Annual Meeting of the Society of Nuclear Medicine, Taipei, Taiwan.